A5052182784- RNA modifications and cancer
- Liver physiology and pathology
- Cancer, Lipids, and Metabolism
- Macrophage Migration Inhibitory Factor
- Ferroptosis and cancer prognosis
- Animal Disease Management and Epidemiology
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Apelin-related biomedical research
Shanghai University of Traditional Chinese Medicine
2021-2025
Shanghai University of Medicine and Health Sciences
2025
Liaocheng University
2025
China Medical University
2025
First Hospital of China Medical University
2025
Seventh People's Hospital of Shanghai
2021
National Institutes of Health
1996
National Cancer Institute
1995
Introduction: Non-small cell lung cancer (NSCLC) is a lethal type of (LC) with 5-year survival rate 19%. Because drug resistance typically develops following chemotherapy, radiotherapy, and immunotherapy, novel NSCLC therapeutic strategy urgently demanded. Gambogenic acid (GNA), major bioactive ingredient isolated from gamboge, has multipotent antitumor effects, although activity against unknown. Methods: CCK8, ethynyl deoxyuridine (EdU), the plate colony formation assay, transwell wound...
Macrophage-stimulating protein (MSP) was originally identified as an inducer of murine resident peritoneal macrophage responsiveness to chemoattractants. We recently showed that the product RON, a tyrosine kinase cloned from human keratinocyte library, is receptor for MSP. Similarity stk RON led us determine if gene Radiolabeled MSP could bind NIH 3T3 cells transfected with cDNA (3T3/stk). Binding saturable and inhibited by unlabeled but not structurally related proteins, including...
Macrophage stimulating protein (MSP), which is secreted as biologically inactive pro-MSP, activated to MSP by cleavage at a single peptide bond. Our objectives were determine the form of in circulating blood and study proteolytic activation pro-MSP its target cell. Western blot immunoaffinity-purified serum showed that all was without detectable MSP. The therefore conversion does not occur when shed. Incubation radiolabeled with murine peritoneal macrophages caused predominantly fragments....
The growing recognition of the role milk-derived exosomes in metabolic and immunological processes has brought attention to potential utility donkey milk. However, efficacy bioactive components milk are underexplored. This study aimed elucidate proteomic profiles isolated from colostrum mature using advanced four-dimensional (4D) label-free quantitative proteomics. A comprehensive analysis identified quantified a total 2293 exosomal proteins milk, including 276 differentially expressed...