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A5093896543
Research Areas
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
Sumitomo Bakelite (Japan)
2024
Abstract The small intestine and liver play important role in determining oral drug's fate. Both organs are also interconnected through enterohepatic circulation, which imply there crosstalk circulating factors such as signaling molecules or metabolites that may affect drug metabolism. Coculture of hepatocytes intestinal cells have shown to increase hepatic metabolism, yet its mechanism is still unclear. In this study, we aim elucidate by coculturing primary human harvested from chimeric...
10.1093/pnasnexus/pgae070
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PNAS Nexus
2024-02-01
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