A5064445792- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Mesenchymal stem cell research
- COVID-19 diagnosis using AI
- Pulmonary Hypertension Research and Treatments
- Occupational and environmental lung diseases
- Microplastics and Plastic Pollution
- Polymer crystallization and properties
- biodegradable polymer synthesis and properties
Universitat de les Illes Balears
2023-2024
Idiopathic pulmonary fibrosis (IPF) is characterized by an aberrant repair response with uncontrolled turnover of extracellular matrix involving mesenchymal cell phenotypes, where lung resident stem cells (LRMSC) have been supposed to important role. However, the contribution LRMSC in not fully understood, and role IPF remains be elucidated. Here, we performed transcriptomic functional analyses on isolated from control patients (CON). Both over-representation gene set enrichment indicated...
Lung-resident mesenchymal stem cells (LR-MSC) are thought to participate in idiopathic pulmonary fibrosis (IPF) by differentiating into myofibroblasts. On the other hand, LR-MSC IPF patients present senescence-related features. It is unclear how they respond a profibrotic environment. Here, we investigated response of isolated from and control (CON) patients. were inoculated mice 48 h after bleomycin (BLM) instillation analyze their contribution lung damage. In vitro, exposed TGFβ. Mice with...