Occupational noise-induced hearing loss (NIHL) is one of the most prevalent occupational diseases worldwide. Few studies have been reported on applying kurtosis-adjusted noise energy (e.g., cumulative exposure, CNE-K) as a joint indicator for assessing NIHL. This study aimed to analyze effectiveness CNE-K in associated with complex typical manufacturing industries.A cross-sectional survey 1404 Chinese workers from industries was conducted. General demographic characteristics, exposure data,...

The usefulness of heart rate variability (HRV) in the clinical research has been verified numerous studies. However, it is controversy that using pulse (PRV) as a surrogate HRV different applications.We aimed to investigate whether PRV extracted from finger photoplethysmography (Pleth) signal could substitute ECG during sleep stages by analyzing common time-domain, frequency-domain and non-linear indices.Seventy-five apnea patients were enrolled. For each patient, Pleth signals...

A nationwide sample of university students completed a survey that asked questions about their perceptions the factors can cause problems which exist with online or general group work. Data were obtained from 173 at more than 18 different universities in United Kingdom. Three main collaboration are identified through an extensive review literature and addressed as problem scenarios survey. These include: poor motivation, lack individual accountability negative interdependence. Findings...

Many factors could affect the achievement of students in distance learning settings. Internal such as age, gender, previous education level and engagement online activities can play an important role obtaining successful outcomes, well external regions where they come from environment that access. Identifying relationships between student characteristics outcomes is a central issue analytics. This paper presents study applies unsupervised for identifying how demographic their achievement. We...

Abstract Aim To compare thermocoagulation and cryotherapy for treatment of high‐grade cervical intraepithelial neoplasia (CIN). Methods From May 2017 to 2018, women with CIN2/3 were randomized or at Peking University Shenzhen Hospital. Follow‐up 4 8 months included cytology human papillomavirus (HPV) testing. Women who HPV‐positive had atypical squamous cells undetermined significance higher‐grade disease underwent colposcopy/biopsy. Results Among 149 enrolled, 74 thermocoagulation, 75...

Abstract Background The associations of the proportion vigorous physical activity (VPA) to moderate (MVPA) with incident cardiovascular disease (CVD) and all-cause mortality are unclear. Methods present study included 366,566 participants (aged 40–69 years) without baseline CVD from UK biobank during 2006 2010. Cox regression was used calculate hazard ratios (HRs) 95% confidence intervals (CIs) for risks outcomes. Results During a median 11.8 years follow-up, among (mean age [SD]: 56.0...

Rationale: Maintenance hemodialysis (MHD) represents a crucial form of renal replacement therapy for patients suffering from end-stage disease. These MHD individuals are especially susceptible to pulmonary infections due compromised immune defenses. High throughout metagenomic sequencing technologies allow the precise identification pathogens at genetic level, leading personalized treatment plans that improve patient outcomes. This case first reported instance mixed infection with...

Recent work has highlighted how consideration of learning styles in the process group formation for collaborative can have a positive impact. This paper investigates performance similar style groups and diverse work, explores grouping algorithm based on students' affects achievements processes. An empirical study with current undergraduate students UK been conducted. The participating were invited to accomplish two discussion tasks. Each student performed activities, separate each time, once...

doi: https://doi.org/10.12669/pjms.39.4.7542
 How to cite this: Liu S, Yu X, Li X. A new promising biological agent for refractory lupus nephritis: Telitacicept. Pak J Med Sci. 2023;39(4):---------. https://doi.org/10.12669/pjms.39.4.7542

Background Noise energy has been well-established to increase the risk of occupational noise-induced hearing loss (NIHL). However, role noise temporal structure (expressed by kurtosis) or its combination with metrics (e.g., kurtosis-adjusted cumulative exposure, adj-CNE) in NIHL was still unclear. Methods A cross-sectional survey 867 Chinese workers, including 678 metal manufacturing workers and 189 exposed Gaussian noise, conducted. metrics, L Aeq,8h CNE, kurtosis (β), adj-CNE were used...

To investigate the association of change in leisure-time physical activity (LTPA) occurring during postretirement period with incident stroke.The current study enrolled 12,644 retired workers from Dongfeng-Tongji cohort April to October 2013. The LTPA was categorized as follows, according whether time met WHO recommended minimum (at least 150 minutes per week): (1) stayed inactive at both surveys; (2) 2008 survey but became active 2013 survey; (3) (4) surveys. We used multivariable-adjusted...

Pentraxin 3 (PTX3) has been associated with the development and progression of various malignant tumors. However, its roles mechanisms underlying involvement in ovarian cancer (OC) peritoneal metastasis remain unclear. Single-cell RNA sequencing (scRNA-seq) immunohistochemistry (IHC) were conducted to determine expression profiles, potential functionalities, PTX3 within context OC. To assess proliferative response OC cells, we utilized both EdU (5-ethynyl-2' -deoxyuridine) CCK8 assays. The...

doi: https://doi.org/10.12669/pjms.39.4.7559
 How to cite this: Li X, Liu S. Who’s blame for central venous stenosis. Pak J Med Sci. 2023;39(4):---------.

Antibody-associated vasculitis (AAV) is a systemic autoimmune disease, with hormones and immunosuppressants as its main treatment measures. However, during the process, various infections such lung urinary tract are prone to occur, patients OMSI relatively rare. The present case report describes of young woman who received long-term oral glucocorticoids immunosuppressive agents for antineutrophil cytoplasmic (AAV). At hospital admission, patient high fever painful swelling left side mouth....

Abstract Our previous studies showed that Shikonin (SK) had a strong anti- Candida albicans ( C. ) activity, especially against some fluconazole-resistant strains, which is probably due to the oxidative damage of SK . In this study, we further analyze exact mechanism Through experiments, such as detecting apoptosis and necrosis rates SC5314 cells treated with different concentrations by Annexin V-FITC / PI double staining, observing ultrastructure transmission electron microscopy, testing...