A5031099570- Viral Infections and Vectors
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Enhanced Recovery After Surgery
- Respiratory viral infections research
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Bladder and Urothelial Cancer Treatments
- Bacterial Infections and Vaccines
- Immune Cell Function and Interaction
The University of Texas Medical Branch at Galveston
2019-2024
Abstract Chikungunya virus (CHIKV), which induces chikungunya fever and chronic arthralgia, is an emerging public health concern. Safe efficient vaccination strategies are needed to prevent or mitigate virus-associated acute morbidities for preparation of future outbreaks. Eilat (EILV)/CHIKV, a chimeric alphavirus contains the structural proteins CHIKV non-structural EILV, does not replicate in vertebrate cells. The was previously reported induce protective adaptive immunity mice. Here, we...
An attenuated SARS-CoV-2 virus with modified viral transcriptional regulatory sequences and deletion of open-reading frames 3, 6, 7 8 (∆3678) was previously reported to protect hamsters from infection transmission. Here we report that a single-dose intranasal vaccination ∆3678 protects K18-hACE2 mice wild-type or variant challenge. Compared infection, the induces equivalent higher levels lung systemic T cell, B IgA, IgG responses. The results suggest as an attractive mucosal vaccine...
The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted global public health safety and the economy. Multiple antiviral drugs have been developed, some received regulatory approval and/or authorization. use of nutraceuticals can be beneficial for preventing treating COVID-19 complications. AHCC is a standardized, cultured extract an edible mushroom Lentinula edodes Basidiomycete family fungi that enriched in acylated α-1,4-glucans. Here, we evaluated effects oral...
Abstract Eilat (EILV)/chikungunya virus (CHIKV), an insect-based chimeric alphavirus was previously reported to protect mice months after a single dose vaccination. The underlying mechanisms of host protection are not clearly defined. Here, we assessed the capacity EILV/CHIKV induce quick and durable in cynomolgus macaques. Both live attenuated CHIKV 181/25 vaccine protected macaques from wild-type (WT) infection 1 year Transcriptome functional analyses reveal that triggered T cell, memory B...
An attenuated SARS-CoV-2 virus with modified viral transcriptional regulatory sequences and deletion of open-reading frames 3, 6, 7 8 (∆3678) was previously reported to protect hamsters from infection transmission. Here we report that a single-dose intranasal vaccination ∆3678 protects K18-hACE2 mice wild-type or variant challenge. Compared infection, the induces equivalent higher levels lung systemic T cell, B IgA, IgG responses. The results suggest as an attractive mucosal vaccine...
Abstract Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes acute chikungunya fever (CHIKF) which often accompanied by severe and persistent arthralgia. There are currently no licensed human vaccines against CHIKV. Eilat (EILV), mosquito-specific alphavirus, replicates well in mosquito cells, but not vertebrate cells. EILV/CHIKV chimeric CHIKV vaccine candidate contains the nonstructural proteins of EILV structural This chimera has been shown to protect wild-type (WT)...
Abstract Development of effective SARS-CoV-2 vaccines to induce potent and long-lasting immunity provide cross-reactive protection against emerging variants remains a high priority. We recently reported live-attenuated vaccine candidate with re-engineered viral transcription regulator sequences deleted open-reading-frames (ORF) 3, 6, 7, 8 (Δ3678) is highly attenuated in mice hamsters vaccination Δ3678 protect from wild-type virus challenge transmission. Here we report that single dose...