A5069939077- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Atherosclerosis and Cardiovascular Diseases
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Cancer Treatment and Pharmacology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Fatty Acid Research and Health
- Cardiovascular Issues in Pregnancy
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Cardiac Structural Anomalies and Repair
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Eicosanoids and Hypertension Pharmacology
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Lipid metabolism and biosynthesis
- Sphingolipid Metabolism and Signaling
Ciena (United States)
2024
University Health Network
2011-2016
University of Toronto
2007-2015
Brigham and Women's Hospital
2015
Case Western Reserve University
2015
University School
2015
Kyoto University Hospital
2015
Boston Children's Hospital
2015
Harvard University
2015
Heart and Stroke Foundation
2013-2015
Myofibroblast differentiation induced by transforming growth factor-β (TGF-β) and characterized de novo expression of smooth muscle (SM)-specific proteins is a key process in wound healing the pathogenesis fibrosis. We have previously shown that TGF-β-induced activation serum response factor (SRF) required for this process. In study, we examined signaling mechanism SRF TGF-β as it relates to pulmonary myofibroblast differentiation. stimulated profound, but delayed (18–24 h), Rho kinase...
Abstract Objective Kawasaki disease (KD) is a multisystem vasculitis leading to damage in the coronary circulation and aneurysm formation. Because cardiac tissue from affected children not available, investigation of mechanisms responsible for artery KD requires use model. The present study was undertaken examine, an experimental model, role matrix metalloproteinase 9 (MMP‐9) on inflammation vascular damage. Methods C57BL/6 mice were injected with Lactobacillus casei cell wall extract induce...
Abstract Objective Kawasaki disease (KD) is a multisystem vasculitis affecting children and characterized by immune activation in the acute stage of disease. Systemic inflammation eventually subsides, although coronary arteritis persists, resulting aneurysm formation. KD leading cause acquired heart among North America. Accepted treatment guidelines include high‐dose intravenous immunoglobulin (IVIG) aspirin phase. Although this therapy effective, cellular molecular mechanisms involved are...
Human and murine Vcam1 promoters contain 2 adjacent nuclear factor-κB (NF-κB)-binding elements. Both are essential for cytokine-induced transcription of transiently transfected promoter-reporter constructs. However, the relevance these insights to regulation endogenous gene pathophysiological processes in vivo remained unknown.Determine role 5' NF-κB-binding element expression gene.Homologous recombination embryonic stem cells was used inactivate NF-κB promoter alter 3 nucleotides...
Kawasaki disease (KD) is the leading cause of acquired heart children in North America. It characterized by a massive immune activation and multi-system vasculitis, which evolves into site-specific inflammatory response focused at coronary arteries. Coronary artery (CA) inflammation leads to elastin breakdown, destruction vessel wall aneurysm formation. We have demonstrated recently pivotal role tumour necrosis factor (TNF)-alpha-mediated matrix metalloproteinase (MMP)-9 activity...
Abstract Introduction: Antibody-Drug Conjugates (ADCs) have had tremendous impact on patient outcomes in breast and other cancers. T-DXd, for example, is second-line therapy stage IV, HER2 positive metastatic cancer as well low expressing tumors. Sacituzumab govitecan, a TROP2 targeted ADC, has been approved 3rd line locally advanced or negative cancer. However, many patients fail to respond relapse after treatment with ADC therapies due tumor heterogeneity eventual resistance the payload....
Abstract Introduction: ADCs have had tremendous impact on patient outcomes in breast cancer and are now second line therapy for stage IV HER2 positive metastatic cancer. However, many patients fail to respond or relapse after treatment with ADC therapies due tumor heterogeneity resistance payloads. We developing next generation that deliver targeted combination chemotherapies a single molecule. Method: CatenaBio has developed novel system capable of attaching distinct payloads at different...
Abstract Background: ADCs have had tremendous impact on patient outcomes in breast cancer and are rapidly moving towards second line use. However, many patients fail to respond or relapse after treatment with ADC therapies due tumor heterogeneity resistance payloads. Method: CatenaBio has developed a novel Multi-Payload-Conjugate (MPC) system capable of attaching distinct payloads at different sites the same antibody, enabling production single-molecule targeted combination defined DAR....
The inflammasome consists of an innate immune receptor, the adaptor molecule ASC, and effector Caspase-1 that is responsible for processing signature cytokines such as IL-1beta. exact role in atherosclerosis not clear since both pathogenic dispensable roles have been reported. Notably, ASC has functions may impact but are unrelated to inflammasome, example induction apoptosis regulation pro-inflammatory transcription factors. various (i.e. IL-1beta processing, cell death, NF-kappaB AP-1...
Dendritic cells (DCs) play a key role in chronic inflammatory diseases such as atherosclerosis. Myeloid with features of DCs are abundant the normal arterial intima mice, regions that predisposed to Upon induction hypercholesterolemia, these intimal rapidly engulf lipids and transform into initial foam nascent atherosclerotic lesions. The function mice remains unknown. We observed systemic stimulation toll-like receptors (TLRs), specifically TLR4 by LPS TLR3 Poly(I:C), induced rapid...
High concentrations of circulating extracellular vesicles (EVs) are present in the blood, and their levels contents altered several disease states, including cardiovascular disease. However, function EVs − especially microRNAs that they contain poorly understood. We sought to determine effect secreted produced by quiescent endothelial cells (ECs) on monocyte inflammatory responses, assess whether transfer occurs between these cells. observed monocytes co-cultured (but not contact) with ECs...
Introduction: Kawasaki Disease (KD) is a multi-system vasculitis leading to coronary artery damage. Previous work has shown that co-stimulatory signals can rescue subset of superantigen (SAg) reactive T-cells from apoptosis and one the major pathways responsible for delivery this signal CD28 signaling on T-cells. Lactobacillus casei cell wall extract (LCWE) contains SAg among its active ingredients, induction arteritis in mice closely resembles human KD. Methods: Flow cytometry was used...