A5012825115- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Skin Protection and Aging
- Hepatitis C virus research
- Pharmacogenetics and Drug Metabolism
- Diet and metabolism studies
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Hepatitis B Virus Studies
- Acne and Rosacea Treatments and Effects
- Poisoning and overdose treatments
- Pregnancy and Medication Impact
- Digestive system and related health
- Pain Mechanisms and Treatments
- Photodynamic Therapy Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Pain Management and Opioid Use
- Diet, Metabolism, and Disease
- Organ Donation and Transplantation
- Pathogenesis and Treatment of Hiccups
- melanin and skin pigmentation
- Vitamin C and Antioxidants Research
- Pharmacological Effects and Toxicity Studies
Consumer Healthcare Products Association
2012-2024
Janssen (United States)
2024
Johnson & Johnson (United States)
2017-2023
Johnson & Johnson (Sweden)
2020
Bristol-Myers Squibb (Germany)
2007
Sharp Memorial Hospital
2004
Mount Sinai Hospital
2004
Baylor University
2004
Icahn School of Medicine at Mount Sinai
1995-2001
The University of Texas Southwestern Medical Center
1999
Little information is available on acute liver failure (ALF) in the United States. We gathered demographic data retrospectively for a 2-year period from July 1994 to June 1996 all cases of ALF 13 hospitals (12 transplant centers). Data patients included age, hepatic coma grade admission, presumed cause, transplantation, and outcome. Among 295 patients, 74 (25%) survived spontaneously, 121 (41%) underwent 99 (34%) died without undergoing transplantation. Ninety-two (76%) 1 year after...
ABSTRACT Acetaminophen (APAP) has been formulated as immediate‐, modified‐, and extended‐release tablets (APAP‐IR, ‐MR, ‐ER, respectively). However, there was concern that APAP‐MR previously available in Europe could form a bezoar after large overdose, leading to delayed absorption atypical pharmacokinetics (PK) compared APAP‐IR, current treatment guidelines developed for APAP overdose prevent severe hepatotoxicity are inappropriate APAP‐MR. In contrast, APAP‐ER caplets the United States...
Context.—Before the development of human colonic neoplasms, epithelial cells showed altered growth and differentiation. These alterations characterized mucosa at risk for cancer formation were termed intermediate biomarkers risk. Modifications toward more normal features by nutrients or drugs are putative approaches to chemoprevention colon cancer.Objective.—To determine whether increasing calcium intake via dairy products alters normal.Design.—Randomized, single-blind, controlled...
Wilson's disease is an inherited disorder of copper metabolism characterized by reduced biliary excretion, which results in accumulation tissues with liver injury and failure. Orthotopic transplantation (OLT) can be lifesaving for patients who present fulminant failure unresponsive to medical therapy. The aim this study review our experience OLT disease.Between 1988 2000, 21 OLTs were performed 17 disease. Patient demographics, pre-OLT laboratory data, operative early late postoperative...
Hepatic venous outflow obstruction caused by hepatic vein thrombosis (HVT) is a manifestation of hypercoagulable state, most commonly myeloproliferative disorder (MPD). In the past, HVT was thought to have poor prognosis unless treated surgically with portosystemic shunt or orthotopic liver transplantation (OLT). The aim this study assess whether early diagnosis underlying hematologic and institution appropriate medical therapy altered outcome. We reviewed charts 22 patients evaluated at our...
This study was conducted to understand the symptomatology, attitudes, and behaviours of chronic hepatitis B (CHB) patients in USA. CHB enrolled this were recruited through multiple methods, including newspaper advertisements. Interviews languages, all participants had a history infection for at least 6 months. Patients with documented human immunodeficiency virus or C coinfection excluded from data analyses, resulting total population 258 respondents who completed interviews between April...
In 2019, the California Office of Environmental Health Hazard Assessment (OEHHA) initiated a review carcinogenic hazard potential acetaminophen. The objective analysis herein was to inform this by assessing whether variability in patient baseline characteristics (e.g. glutathione (GSH) levels, pharmacokinetics, and capacity hepatic antioxidants) leads differences at different dosing schemes: maximum labeled doses 4 g/day, repeated above dose (>4–12 g/day), acute overdoses acetaminophen (>15...
Holt, Peter R.; Atillasoy, Evren O.; Gilman, Jody; Guss, Janet; Moss, Steven F.; Newmark, Harold; Fan, Kunhua; Yang, Kan; Lipkin, Martin
Background: Excessively high doses of loperamide (of up to 792mg/day) have recently been associated with reports cardiac events.However, no data currently demonstrate a direct effect on the occurrence cardiovascular abnormalities. Objectives:To assess effects QT/corrected QT (QTc) intervals, electrocardiogram (ECG) morphology, and overall safety tolerability at therapeutic supratherapeutic exposures in healthy adults.Methods: This randomized, double-blind, four-way-crossover study enrolled...
Hepatitis C virus (HCV) infection is associated with development of hepatocellular carcinoma (HCC). The aim this study was to examine clinical characteristics and outcome patients HCV or without HCC undergoing liver transplant.We reviewed the charts all 55 transplanted between November 1990 December 1996 for cirrhosis compared them a control group HCC. Patients history alcohol abuse HBsAg positivity were excluded. There 37 men 18 women, mean age 57.6 yr (range, 19-70 yr) in group.There no...
This is a case report of 43-year-old woman who received transplant for end-stage liver disease due to hereditary hemorrhagic telangiectasia and fibropolycystic disease. an uncommon association two autosomal-dominant conditions with defined genetic molecular defects. The showed extensive vascular malformations arteries veins as well fibrosis. In addition, there were cystically dilated ducts containing inspissated bile von Meyenburg complexes. raises interesting questions about the possible...