A5049038356- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- RNA modifications and cancer
- Microbial Metabolic Engineering and Bioproduction
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
European Institute of Oncology
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Chromosomal instability (CIN) generates micronuclei-aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are characterized by persistent DNA damage and catastrophic nuclear envelope collapse, which exposes to cytoplasm. We found autophagic receptor p62/SQSTM1 modulates micronuclear stability, influencing chromosome fragmentation rearrangements. Mechanistically, proximity micronuclei mitochondria led...
Transcription termination pathways mitigate the detrimental consequences of unscheduled promiscuous initiation occurring at hundreds thousands genomic cis -regulatory elements. The Restrictor complex, composed Pol II-interacting protein WDR82 and RNA-binding ZC3H4, suppresses processive transcription extragenic sites in mammalian genomes. Restrictor-driven does not involve nascent RNA cleavage, its interplay with other machineries is unclear. Here we show that efficient Restrictor-controlled...
Abstract The histone demethylase LSD1 is over-expressed in hematological tumors and has emerged as a promising target for anticancer treatment, so that several inhibitors are under development testing, preclinical clinical settings. However, the complete understanding of their complex mechanism action still unreached. Here, we unraveled novel mode MC2580 DDP-38003, showing they can induce differentiation AML cells through downregulation chromatin protein GSE1. Analysis phenotypic effects...
Abstract The histone de-methylase LSD1 is over-expressed in haematological tumours and has emerged as a promising target for anti-cancer treatment, so that several inhibitors are under development testing, pre-clinical clinical settings. However, the complete understanding of their complex mechanism action still unreached. Here, we unravelled novel mode MC2580 DDP-38003, showing they can induce differentiation AML cells through down-regulation chromatin protein GSE1. Analysis phenotypic...