A5047483683- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Electron Spin Resonance Studies
- Cancer, Hypoxia, and Metabolism
- Lanthanide and Transition Metal Complexes
- Ultrasound and Cavitation Phenomena
- MRI in cancer diagnosis
Jagiellonian University
2022-2025
The precise and real-time measurement of oxygen partial pressure (pO2) brings valuable information in many pathologies, including cancer. Low tumor pO2 (i.e., hypoxia) is connected to aggressiveness poor response therapy. quantification allows the evaluation treatment effectiveness. Electron Paramagnetic Resonance Imaging (EPRI), particularly Pulse EPRI, has emerged as an advanced three-dimensional (3D) method assessing tissue oxygenation vivo. This innovation was enabled by technological...
Low tissue oxygenation significantly impairs the effectiveness of cancer therapy and promotes a more aggressive phenotype. Many strategies to improve have been proposed throughout years, but only few showed significant effects in clinical settings. We investigated stability ultrasound pulse (UP) triggered oxygen release from phospholipid coated microbubbles (OMB) vitro murine tumors vivo using EPR oximetry. In solution, are stable responsive pulse. The addition OMB solution alone resulted an...
The inadequate level of oxygenation in tumors has been shown to correlate not only with greater invasiveness cancer cells, but also a reduction their sensitivity anticancer therapies. Over the years, many attempts have made increase cancer, most them ineffective. We investigated heterogeneous response tumor tissue phospholipid-coated oxygen microbubbles (OMB) murine vivo using and hemoglobin saturation mapping influence OMB treatment on microvasculature, perfusion, radiotherapy...
Radiotherapy is a cornerstone of cancer treatment, but tumor hypoxia and resistance to radiation remain significant challenges. Vascular normalization has emerged as strategy improve oxygenation enhance therapeutic outcomes. In this study, we examine the radiosensitization potential vascular using metformin, widely used anti-diabetic drug, oxygen microbubbles (OMBs). We investigated synergistic action metformin OMBs impact combination on vasculature, oxygenation, invasiveness,...
The goal of this work was to compare pO