A5024363412- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Gut microbiota and health
- Cerebrovascular and genetic disorders
- Barrier Structure and Function Studies
- Neurological Disorders and Treatments
- Immune cells in cancer
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Telomeres, Telomerase, and Senescence
- Immune Response and Inflammation
- Intracranial Aneurysms: Treatment and Complications
- COVID-19 Clinical Research Studies
- Inflammation biomarkers and pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intensive Care Unit Cognitive Disorders
- Advanced Glycation End Products research
- Cell Adhesion Molecules Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
Tulane University
2022-2025
Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many the current therapies have shown success in reducing mortality, post-stroke morbidity has not seen same substantial reduction. Recently, involvement cellular senescence SASP brain injury neurological degeneration been recognized. Ischemic causes oxidative stress mitochondrial damage that induces through activation p21 p16 pathways, ultimately leading to synthesis release...
Introduction: SARS-CoV-2 causes various neurological sequelae in COVID-19 survivors including fatigue and cognitive dysfunction. Endothelial dysfunction, a key mechanism illness, is also major risk factor for vascular dementia (VaD). Clinical evidence suggests that reduced nitric oxide (NO) bioavailability likely pathogenic of endothelial dysfunction patients, eNOS levels decline with advancing age, both morbidity VaD . We hypothesize synthase (eNOS) deficiency contributes to brain infection...
Introduction: Ischemic stroke is a devastating brain injury and leading cause of mortality morbidity worldwide. Age the most influential co-morbidity, modulating severity, occurrence, cognitive impact. We have previously found that causes marked increase in cellular senescence senescence-associated secretory phenotype (SASP). In aged brain, cells develop into SASP which induces neuroinflammation further transform healthy cell to senescent (SC) via paracrine signaling. Although there baseline...
Inflammation is a key contributor to stroke pathogenesis and exacerbates brain damage leading poor outcome. Interleukin-1 (IL-1) an important regulator of post-stroke inflammation, blocking its actions beneficial in pre-clinical models safe the clinical setting. However, distinct roles two major IL-1 receptor type 1 agonists, IL-1α IL-1β, specific role ischemic remain largely unknown. Here we show that IL-1β have different spatio-temporal expression profiles after experimental stroke, with...
Introduction: Although SARS-CoV-2 infection can cause a wide range of mild to severe symptoms, the pathophysiology acute and long-term neurological manifestations remains elusive. The arginine-glycine-aspartic acid motif viral spike protein may use bind integrins receptors in CNS, which play an important role cerebrovascular integrity. Here we investigate integrin α5β1 mediating brain endothelial damage inflammation during infection. Method: Mouse microvascular cells (bEnd.3) were treated...
Abstract Inflammation is a key contributor to stroke pathogenesis and exacerbates brain damage leading poor outcome. Interleukin-1 (IL-1) an important regulator of post-stroke inflammation, blocking its actions beneficial in pre-clinical models safe the clinical setting. However, distinct roles two major IL-1 receptor type 1 agonists, IL-1α IL-1β, specific role ischemic remain largely unknown. Here we show that IL-1β have different spatio-temporal expression profiles after experimental...
Clinical studies strongly suggest the importance of diet quality on cognition in youth populations (15-24 years). The Mediterranean (MeDi) has been shown to improve contrast commonly consumed Western (WD). gut microbiota may serve as a mechanism for diet-induced changes cognition. Ten-week-old male Sprague Dawley rats were assigned MeDi or WD (n=10/group) 14 weeks. Prior neurobehavior assessments, community composition was assessed. At genus level, relative abundance four bacteria increased...
The gut-microbiome-brain axis is an underexplored mechanism that may mitigate the development of mild cognitive impairment. objective this study was to elucidate effects a human-modeled Mediterranean diet (MeDi) and Western (WD) on function gut microbial composition. We hypothesized consumption MeDi would improve modulate beneficial changes microbiota compared WD. Male Sprague Dawley rats (10 weeks age) were assigned (n = 10) or WD 9) for 3 months. radial arm water maze (RAWM) used assess...
Intraluminal monofilament model of middle cerebral artery occlusion (MCAO) is widely adopted for ischemic stroke; and Sprague-Dawley (SD) rats are commonly used rodents preclinical research. Due to the paucity information on appropriate size inducing MCAO in SD importance including middle-aged models stroke studies, we aimed to: (i). determine an Doccol® male which weighed > 500 g following 24-h transient survival as well (ii). demonstrate optimal filament males (≤ g) females (273-300 while...
Abstract Background Alterations in the gut microbiota have been observed patients with mild cognitive impairment and Alzheimer’s disease. Dietary consumption directly modulates microbiota; therefore, quality of a diet may impact function susceptibility to dementia. We hypothesized that nutrient dense Mediterranean (MeDi) would improve through beneficial changes as compared primarily consumed by Americans, Western (WD). Method Ten‐week‐old Sprague Dawley male rats were assigned MeDi (n = 10)...
Abstract Background Many patients with mild cognitive impairment and Alzheimer’s disease have alterations in the gut microbiota. Dietary consumption directly modulates microbiota; therefore, quality of a diet may impact function susceptibility to memory impairments. We hypothesized that Mediterranean (MeDi) versus Western (WD) will improve through beneficial changes Method Twelve‐month‐old male Fischer 344 rats (n = 14/group) were randomly assigned MeDi, WD, or Chow (positive control MeDi)...
Patients with significant cerebrovascular comorbidities (e.g. brain ischemia, vascular dementia) are more affected and likely to have worsened post-acute neurologic sequelae after SARS-CoV-2 infection. This may be due viral invasion propagation in endothelial cells (BECs) disruption of the blood-brain barrier (BBB). Viral spike protein used bind infect host encodes an arginine-glycine-aspartic acid (RGD) motif that it use integrins cell receptors play important role integrity. Therefore,...
Stroke remains the second leading cause of death globally, with a total 5.5 million deaths in 2016 and an estimated global lifetime risk stroke for those aged 25 years or older at 24.9%. A key feature poststroke injury is inflammatory response, which driven by variety pro-inflammatory cytokines to include interleukin-1 (IL-1). Evidence from pre-clinical studies have demonstrated deleterious effect IL-1 beneficial observed after blocking both clinical settings. The family has IL-1β IL-1α...