A5044204681- Cardiac Fibrosis and Remodeling
- Heart Rate Variability and Autonomic Control
- Exercise and Physiological Responses
- Congenital heart defects research
- Ion channel regulation and function
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Tissue Engineering and Regenerative Medicine
- Physiological and biochemical adaptations
- Cardiac electrophysiology and arrhythmias
York University
2024
Siemens Healthcare (United States)
2017
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia that strongly associated with cardiovascular (CV) disease and sedentary lifestyles. Despite the benefits of exercise on overall health, AF incidence in high-level endurance athletes rivals CV patients, suggesting J-shaped relationship AF. To investigate dependence vulnerability exercise, we varied daily swim durations (120, 180 or 240 min day
Mitochondria exhibit high levels of adaptability to various stimuli such as chronic muscle use (i.e. exercise) or disuse, immobilization denervation. These changes in the mitochondrial network ultimately affect health and functioning skeletal muscle, which contributes whole-body metabolism, locomotion, postural stability. It is now acknowledged that dysfunction can activate inflammatory pathways through recognition damage-associated molecular patterns (DAMPs). The objective this study was...
Introduction: Cardiac fast transient outward potassium currents (I to,f ) are formed by KCND2 (Kv4.2) and KCND3 (Kv4.3) channels in mice primarily humans. Rapid I activation induces early phase 1 repolarization of action potentials (APs), which has been linked strongly to the modulation excitation-contraction coupling (ECC). Consequently, variations densities underlie regional differences ventricular APs myocardial contractile properties. To investigate further role cardiac function, we...
Background:The 2015 European Society of Cardiology guidelines propose algorithms for faster rule-in or rule-out AMI in patients admitted the acute care setting, and management NSTEMI.Serial measurements with high sensitivity troponin I assays will more accurately precisely measure changes cardiac (cTnI) concentrations providing useful data to assist identifying versus chronic cTnI elevations, acceptable performance within 1 3-hours presentation.The Siemens assay1 (TNIH) being developed use...