A5081942840- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Silk-based biomaterials and applications
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Voice and Speech Disorders
- MicroRNA in disease regulation
- Advanced Sensor and Energy Harvesting Materials
- Calpain Protease Function and Regulation
- Extracellular vesicles in disease
- Laser Applications in Dentistry and Medicine
- Connective Tissue Growth Factor Research
- Pediatric Pain Management Techniques
- Graphene and Nanomaterials Applications
- Knee injuries and reconstruction techniques
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2025
Chongqing Medical University
2020-2025
Chengdu Women's and Children's Central Hospital
2021
Abstract Chronic hyperglycemic damage is a major problem that undermines diabetic wound healing. By combining treatment and diagnosis together, blood glucose concentration can be monitored real‐time through medical imaging devices precise interventions carried out at the right time to promote repair. In this study, an injectable self‐healing hyaluronic acid hydrogel constructed using Schiff base reaction, nanoenzymes (GOx‐MnO 2 ) synthesized by condensation along with vascular endothelial...
Synovial fibrosis is a characteristic symptom of osteoarthritis (OA), which closely associated with joint pain and stiffness. Previous studies have reported that low-intensity pulsed ultrasound (LIPUS) can alleviate cartilage degradation in OA. However, the functions mechanisms LIPUS OA synovial are still unknown.The destabilization medial meniscus (DMM) mouse model was established C57 male mice fibroblast-like synoviocytes (FLS) were isolated from tissue patients. The knee diameter,...
Cellular senescence is an important cause of age-related degenerative diseases, including osteoarthritis (OA). Chondrocyte crucial in OA onset and progression. As a non-invasive, safe, widely used physical rehabilitation factor, the effect mechanism low intensity pulsed ultrasound (LIPUS) on chondrocyte remain unclear. This study evaluated inhibitory LIPUS vitro vivo. The was examined by RT-qPCR, enzyme-linked immunosorbent assay (ELISA), western blotting. Changes levels reactive oxygen...
Abstract Osteoarthritis (OA) is a degenerative disease which places an enormous burden on society, effective treatments are still limited. As non‐invasive and safe physical therapy, low‐intensity pulsed ultrasound (LIPUS) can alleviate OA progression, but the underlying mechanism not fully understood, especially mechanical transduction between LIPUS organism. In this pioneering study, biomechanical effects of living mice chondrocytes body zebrafish investigate by using fluorescence imaging...
Low-intensity pulsed ultrasound (LIPUS), a noninvasive physical therapy, was recently demonstrated to be an effective treatment for osteoarthritis (OA). Vascular endothelium growth factor A (VEGFA) has been found upregulated in the articular cartilage, synovium and subchondral bone of OA patients, leading cartilage degeneration, synovitis osteophyte formation. However, functions mechanisms LIPUS regulating chondrocyte-derived VEGFA expression are still unclear. In this study, we investigated...
Abstract The malignant cycle of synovitis considerably impacts the progression osteoarthritis (OA). Therefore, precise localization synovitis, targeted disruption inflammatory cycle, and real‐time monitoring its dynamics are crucial for effective diagnosis management OA. Here, porous HAMA/GelMA microspheres synthesized using microfluidic technology. Interleukin‐10 (IL‐10) nanobubbles, prepared via double emulsification, grafted with folic acid (FA) an amide reaction subsequently impregnated...