A5046359385- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Marine Bivalve and Aquaculture Studies
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Marine and fisheries research
- Aquaculture Nutrition and Growth
- T-cell and B-cell Immunology
- Game Theory and Voting Systems
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Gene expression and cancer classification
- Hepatitis C virus research
- interferon and immune responses
Zhejiang Ocean University
2024
Shanghai Stomatological Hospital
2023
Fudan University
2023
Tohoku Medical and Pharmaceutical University
1999
Abstract Although immunotherapy can prolong survival in some patients with head and neck squamous cell carcinoma (HNSCC), the response rate remains low. Clarification of critical mechanisms regulating CD8+ T-cell infiltration dysfunction tumor microenvironment could help maximize benefit for treating HNSCC. Here, we performed spatial transcriptomic analysis HNSCC specimens differing immune single-cell RNA sequencing five pairs adjacent tissues, revealing specific cancer-associated fibroblast...
T‐cell precursors differentiate into mature T cells predominantly in the thymus. However, it has also been reported that extrathymic organs such as liver, bone marrow, or intestines. In order to investigate nature of microenvironment supports maturation, we examined effect a marrow‐derived stroma cell line, ST2, on by using reaggregate thymic organ culture (RTOC) system. We found ST2 supported differentiation fetal thymocytes at day 14·5 gestation from CD4 − CD8 double negative (DN) +...
<p>This file includes Figure S1-S8 and their figure legends.</p>
<p>This file includes Figure S1-S8 and their figure legends.</p>
<div>Abstract<p>Although immunotherapy can prolong survival in some patients with head and neck squamous cell carcinoma (HNSCC), the response rate remains low. Clarification of critical mechanisms regulating CD8<sup>+</sup> T-cell infiltration dysfunction tumor microenvironment could help maximize benefit for treating HNSCC. Here, we performed spatial transcriptomic analysis HNSCC specimens differing immune single-cell RNA sequencing five pairs adjacent tissues,...
<div>Abstract<p>Although immunotherapy can prolong survival in some patients with head and neck squamous cell carcinoma (HNSCC), the response rate remains low. Clarification of critical mechanisms regulating CD8<sup>+</sup> T-cell infiltration dysfunction tumor microenvironment could help maximize benefit for treating HNSCC. Here, we performed spatial transcriptomic analysis HNSCC specimens differing immune single-cell RNA sequencing five pairs adjacent tissues,...
In the process of ascending and descending in deep-sea submerging lifting cage nets, accompanied by changes water pressure, pressure is one crucial environmental factors affecting physiology growth fish. It directly relates to comfort farmed fish cage, thereby influencing quality aquaculture, especially for high-demanding species on culture environment like Larimichthys crocea . Investigating stress level exhibited L.crocea under variations, understanding limit tolerance its changes, can...