A5111561579- Plant and animal studies
- Prenatal Screening and Diagnostics
- Genetic diversity and population structure
- Cytomegalovirus and herpesvirus research
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Genomic variations and chromosomal abnormalities
- Animal Behavior and Reproduction
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Insect-Plant Interactions and Control
- Cervical Cancer and HPV Research
- Cytokine Signaling Pathways and Interactions
- HIV Research and Treatment
- NF-κB Signaling Pathways
Illumina (United States)
2024-2025
University of Bristol
2024-2025
Polygenic Risk Scores (PRS) have enabled quantification of genetic risk for many common and complex traits. Here we developed a novel method to estimate maternal PRS using low-coverage whole genome sequencing data from prenatal screening by cell-free DNA intended screen fetal chromosomal aneuploidies. A prospective study was conducted where 455 consented patients that performed as part their standard care were randomly selected. Cell-free genomic isolated the plasma buffy coat blood drawn...
Identifying the genes and mutations that drive phenotypic variation which are subject to selection is crucial for understanding evolutionary processes. Mormon Fritillary butterflies (Speyeria mormonia) exhibit a striking wing color polymorphism throughout their range: typical morphs bear silver spots on ventral surfaces can co-occur with unsilvered displaying dull coloration.1 Through genome-wide association studies in two polymorphic populations, we fine-map this difference silvering 3'...
Polygenic Risk Scores (PRS) have enabled quantification of genetic risk for many common and complex traits. Early detection may improve patient care health management. In addition, the ability to calculate PRS from pre-existing high throughput standard workflows could allow quicker adoption evidence generation. One potential avenue is leveraging prenatal screening by cell-free DNA (cfDNA) data maternal as part pregnancy Here we developed a novel method estimate using low-coverage (0.25x)...
Summary Identifying the genes and mutations that drive phenotypic variation which are subject to selection is crucial for understanding evolutionary processes. Mormon Fritillary butterflies ( Speyeria mormonia ) exhibit a striking wing color polymorphism throughout their range: typical morphs bear silver spots on ventral surfaces, can co-occur with unsilvered displaying dull coloration 1 . Through genome-wide association studies in two polymorphic populations, we fine-map this difference...