A5054129482- RNA Research and Splicing
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Experimental Behavioral Economics Studies
- Genomics and Chromatin Dynamics
- Open Source Software Innovations
- Viral-associated cancers and disorders
- Chromosomal and Genetic Variations
- Radiation Therapy and Dosimetry
- Innovation Diffusion and Forecasting
- Nuclear Structure and Function
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
Army Medical University
2023-2025
Sun Yat-sen Memorial Hospital
2025
Sun Yat-sen University
2025
New York State Department of Transportation
2007
Xenotropic and polytropic retrovirus receptor 1 (XPR1), a previously identified cellular for several murine leukemia viruses, plays role in many pathophysiological processes. However, the of XPR1 human cancers has not yet been characterized.Real-time PCR western blotting assay were used to measure expression tongue squamous cell carcinoma (TSCC) tissues. Expression p65 clinical specimens was analyzed using immunohistochemical assay. The function on progression TSCC explored vitro vivo...
Radiotherapy is one of the mainstay treatments for hepatocellular carcinoma (HCC). However, a substantial number patients with HCC develop radioresistance and eventually suffer from tumor progression or relapse, which major impediment to use radiotherapy. Therefore, elucidating mechanisms underlying identifying novel therapeutic targets improve patient prognosis are important in management. In this study, using vitro vivo models, laser microirradiation live cell imaging methods,...
Abstract Aberrant Wnt/β‐catenin signaling is a characteristic feature of colorectal cancer (CRC), therefore, understanding the underlying mechanisms aberrant will improve treatment outcome CRC. Expression MNX1 in paired fresh CRC tissues and corresponding adjacent normal were examined by qPCR Western blotting. The levels paraffin‐embedded specimens detected immunohistochemistry (IHC). role growth proliferation cells was evaluated MTT colony formation assay. Luciferase reporter analysis...
The cell cycle is a highly regulated process in which proteins involved progression exhibit periodic expression patterns, controlled by specific mechanisms such as transcription, translation, and degradation. However, the precise underlying oscillations of mRNA levels regulators are not fully understood. In this study, we observed that stability cyclin D1 (CCND1) fluctuates during cycle, with increased interphase decreased M phase. Additionally, identified key RNA binding protein, positive...
DNA is the core that controls life activities of cells. In eukaryotic cells, dispersedly packaged into multiple strands chromatin to regulate cellular activities, however, underlying logic and significance this configuration remain unclear. mouse pericentromeric satellite from can aggregate form chromocenters [1,2]. Based on microscopic imaging techniques analysis, we further reveal there a non-random recombination aggregation between in different nuclei, leading differentiation nuclear...