A5070116234- Bacterial biofilms and quorum sensing
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cellular Mechanics and Interactions
- Crystallography and molecular interactions
- Photoacoustic and Ultrasonic Imaging
- Cellular transport and secretion
- Bacterial Genetics and Biotechnology
- Photoreceptor and optogenetics research
- Nanoplatforms for cancer theranostics
Brandeis University
2024-2025
University of California, Los Angeles
2021
Optical imaging within the shortwave infrared (SWIR, 1000–2000 nm) region of electromagnetic spectrum has enabled high-resolution and high-contrast in mice, non-invasively. Polymethine dyes, with their narrow absorption spectra high coefficients, are optimal probes for fast multiplexed SWIR imaging. Here, we expand upon multiplexing capabilities by obtaining brighter polymethine dyes varied excitation wavelengths spaced throughout near-infrared (700–1000 region. Building on flavylium dye...
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely bacteria, and only once archaea. We show that uniaxial compression induces haloarchaea, forming tissue-like structures. These archaeal tissues are mechanically molecularly distinct from their unicellular lifestyle, mimicking several eukaryotic features. Archaeal undergo multinucleate stage followed by tubulin-independent cellularization, orchestrated active membrane tension at cell...
Bactofilins are rigid, nonpolar bacterial cytoskeletal filaments that link cellular processes to specific curvatures of the cytoplasmic membrane. Although homologs bactofilins have been identified in archaea and eukaryotes, functional studies remained confined systems. Here, we characterize representatives two families archaeal from pleomorphic archaeon Haloferax volcanii , halofilin A (HalA) B (HalB). HalA HalB polymerize vitro, assembling into straight bundles. polymers highly dynamic...