A5062981375- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Rheumatoid Arthritis Research and Therapies
- Dark Matter and Cosmic Phenomena
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Neutrino Physics Research
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Inflammatory mediators and NSAID effects
- Systemic Sclerosis and Related Diseases
- Pharmaceutical studies and practices
- Chronic Lymphocytic Leukemia Research
- Psoriasis: Treatment and Pathogenesis
- Distributed and Parallel Computing Systems
- Lymphoma Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Biosimilars and Bioanalytical Methods
- Gout, Hyperuricemia, Uric Acid
- Education, Psychology, and Social Research
- Peripheral Artery Disease Management
- Spine and Intervertebral Disc Pathology
- Dermatological and Skeletal Disorders
Comenius University Bratislava
2024-2025
Charles University
2009-2024
Rutherford Appleton Laboratory
2024
University of California, Santa Cruz
2024
Atlas Scientific (United States)
2024
Istanbul University
2024
University Hospital Plzen
2009-2021
Research Institute of Inorganic Chemistry
2018
Danish Cancer Society
2009
Institute of Rheumatology
2009
<h3>Objective:</h3> To evaluate the effect of infliximab dose escalation in incomplete responders a randomised controlled trial. <h3>Methods:</h3> 141 rheumatoid arthritis (RA) patients treated with for 12 months (3 mg/kg; intervals 0, 2, 6 and then 8 weeks) who responded to drug (disease activity score 28 joints (DAS28) decrease >1.2) but were not remission (DAS28 >2.6) enrolled into study. Patients randomly assigned arm A, 3 mg/kg, B, 5 mg/kg every weeks. Outcome measures included...
Objectives. To evaluate the association between metastasis-inducing protein S100A4 and disease activity in patients with RA, to demonstrate effect of TNF-α blocking therapy on plasma levels these patients. Methods. Plasma were analysed 40 anti-TNF-α naive active RA. Of patients, 25 treated adalimumab monitored over time. The conformational form was using size-exclusion gel chromatography. mRNA expression synthesis by RT–PCR ELISA, respectively. Results. Baseline significantly correlated RA...
Aim: To map health-related quality of life (Qol) with clinical parameters BASFI and ASDAS-CRP measure, other covariates.Methods: Our prospective multicenter non-interventional observation study ankylosing spondylitis (AS) collected data about QoL outcomes on the initial four subsequent visits. We employed simple linear regression analysis a cross-sectional dataset, fixed effect, random effect pooled longitudinal dataset.Results: showed that are very strong, robust predictors EQ-5D utilities...
The first objective of our study was to determine the radiation exposure received by patients during tin-filtrated ultra-low-dose computed tomography (TFULDCT) sacroiliac joints and compare those conventional X-ray doses. For comparison, we added a cohort examined low-dose CT (LDCT) without tin filtration. second results TFULDCT in detection sacroiliitis.Our retrospective covered 45 patients, who were for suspected axial spondyloarthritis (AxSpA). group underwent as well radiography (CR);...
Melorheostosis is quite a rare bone disease with still unclear ethiology. Although multifocal affection highly debilitating unfavorable prognosis, there no clear consensus about therapeutical approach. There insufficient evidence in the literature for almost century after first description. Affected has typical appearance of melting wax. Diagnosis usually incidental pain as leading symptom. itself relatively easy, routine X-ray examination sufficient. Even though it could be easily...
Rheumatoid arthritis (RA) is a condition associated with accelerated progression of atherosclerosis in affected individuals. Myocardial assessment using exercise testing such patients, however, often difficult to perform. Our objective was determine the factors severe coronary stenosis computed tomography (CT) angiography arteries asymptomatic patients RA.Forty-four women RA were examined CT detect atherosclerotic involvement and significant (>50 %). findings correlated cardiovascular risk...
Cardiac involvement in systemic sclerosis (SSc) patients affects mortality. magnetic resonance (CMR) is capable of detecting structural changes, including diffuse myocardial fibrosis that may develop over time. Our aim was to evaluate structure and function changes using CMR with SSc without known cardiac disease during a 5-year follow-up find possible correlations selected biomarkers.A total 25 underwent baseline examinations according pre-specified protocol. Standard biochemistry, five...
Cyclosporine A (CsA) is an immunomodulatory agent used in standard immunosuppressive regimens solid organ transplantations as well the treatment of autoimmune diseases such rheumatoid arthritis (RA), systemic lupus and psoriasis. Its activity primarily due to parent drug. However, following oral administration, absorption incomplete varies between individuals. Further, there a dearth pharmacokinetic data for CsA patients compared transplant recipients.The goal this study was investigate...
<h3>Background:</h3> A substantial number of patients with rheumatoid arthritis (RA) continue to experience symptoms despite receiving treatment biologic (b) or targeted synthetic (ts) disease-modifying antirheumatic drugs (DMARDs). This specific group has recently been defined by EULAR as "difficult-to-treat (D2T)" RA [1]. However, determining the optimal approach for D2T remains a challenge [2]. <h3>Objectives:</h3> Therefore, we conducted comparative analysis, evaluating clinical efficacy...
Inhibitory kontrolních bodů (ICIs) jsou monoklonální protilátky s imunomodulačním účinkem, které blokují brzdné mechanismy aktivace T buněk.Léčba ICIs je schválena k terapii řady nádorových onemocnění a u části pacientů byla prokázána signifikantně lepší odpověď na léčbu delší přežití.Tato terapie vede upregulaci imunitního systému výsledným efektem protinádorovou imunitu.Důsledkem i rozvoj imunitně podmíněných nežádoucích účinků (irAE), poměrně časté, mohou postihnout jeden nebo více orgánů...
The aim of the present study was to validate limited sampling strategies (LSS:s) for prediction AUC cyclosporine A (CsA) after first dose in rheumatologic patients.22 patients suffering from rheumathoid arthritis, systemic lupus erythematodus, ankylosing spondylitis dermato(poly)myositis or seronegative spondylarthritis were treated with Neoral® (female/male: 11/3, mean ± SD: age 49 14 y, body weight 75 12 kg, height 166 7 cm, 71 25 mg, per kg 1.0 0.3 mg/kg), Consupren® (7/1, 78 36, 175 8,...
Chronic pain is a common health problem related to most of inflammatory rheumatic disorders. It that has persisted for at least 3 month and cannot be fully relieved by standard medication. 40-60 % patients do not have adequate relief their pain. Paramount in the management chronic assessment its impact on physical psychosocial functioning. Multidisciplinary multimodal approach vital importance. Non-steroidal anti-rheumatic drugs (NSA) been used mainly due strong analgesic effect, especially...
Monitorování sérových biomarkerů během léčby pacientů s revmatoidní atritidou