A5087424208- Nuclear Materials and Properties
- Biochemical Analysis and Sensing Techniques
- Chemical Synthesis and Analysis
- Genomics and Phylogenetic Studies
- Advanced biosensing and bioanalysis techniques
- Thermodynamic and Structural Properties of Metals and Alloys
- Cancer-related molecular mechanisms research
- Phytochemicals and Antioxidant Activities
- Nuclear reactor physics and engineering
- Tea Polyphenols and Effects
- Innovative Microfluidic and Catalytic Techniques Innovation
- Click Chemistry and Applications
- Nuclear and radioactivity studies
- Biochemical and Structural Characterization
- Solid-state spectroscopy and crystallography
- Metabolomics and Mass Spectrometry Studies
- Thermal and Kinetic Analysis
- Graphite, nuclear technology, radiation studies
- Monoclonal and Polyclonal Antibodies Research
- High Temperature Alloys and Creep
- Luminescence Properties of Advanced Materials
- Intermetallics and Advanced Alloy Properties
- Coffee research and impacts
ETH Zurich
2023-2025
Constructor University
2020-2023
Institute of Metallurgy
1991
"VNIINM" named after AA Bochvar
1991
The first drugs discovered using DNA-encoded chemical library (DEL) screens have entered late-stage clinical development. However, DEL technology as a whole still suffers from poor purity resulting in suboptimal performance. In this work, we report technique to overcome issue through self-purifying release of the after magnetic bead-based synthesis. Both and last building blocks each assembled member were linked beads by tethers that could be cleaved mutually orthogonal chemistry. Sequential...
Abstract Cyclic peptides constitute an important drug modality since they offer significant advantages over small molecules and macromolecules. However, access to diverse chemical sets of cyclic is difficult on a large library scale. DNA-encoded Chemical Libraries (DELs) provide suitable tool obtain diversity, but DELs made by standard DEL implementation cannot efficiently explore their conformational diversity. On the other hand, dual-display Encoded Self-Assembling (ESAC) can be used for...
We carried out a human volunteer study with 14 participants, eight of whom were asked to consume one cup coffee at four different time points. Urine samples collected points and analyzed by HPLC-MS analysis. The LC-MS data subjected unsupervised multivariate statistical analysis (principal component analysis) followed supervised (linear discriminant analysis). In an unbiased approach, in the absence preselection filtering, most important features explaining differences between consumers...