A5082393973- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Extracellular vesicles in disease
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- COVID-19 Impact on Reproduction
- Hepatitis C virus research
Philipps University of Marburg
2020-2024
Helmholtz Centre for Infection Research
2020
Abstract Some viruses are rarely transmitted orally or sexually despite their presence in saliva, breast milk, semen. We previously identified that extracellular vesicles (EVs) semen and saliva inhibit Zika virus infection. However, the antiviral spectrum underlying mechanism remained unclear. Here we applied lipidomics flow cytometry to show these EVs expose phosphatidylserine (PS). By blocking PS receptors, targeted by process of apoptotic mimicry, they interfere with viral attachment...
Protein tyrosine phosphatase 1B (PTP1B, also known as PTPN1) is a negative regulator of the leptin and insulin signalling pathways. This great interest PTP1B-knockout mice are protected against development obesity diabetes. Here, we provide evidence for novel function PTP1B that independent its activity, but requires localisation to membrane endoplasmic reticulum. Upon activation pattern recognition receptors, macrophages plasmacytoid dendritic cells from secrete lower amounts type I...
Hepatitis C virus (HCV) infection is tightly connected to the lipid metabolism with droplets (LDs) serving as assembly sites for progeny virions. A previous LD proteome analysis identified annexin A3 (ANXA3) an important HCV host factor that enriched at LDs in infected cells and required morphogenesis. To further characterize ANXA3 function HCV, we performed proximity labeling using ANXA3-BioID2 bait HCV-infected cells. Two of top proteins proximal during were La-related protein 1 (LARP1)...