A5049411475- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Bacterial biofilms and quorum sensing
- Viral Infections and Vectors
- Plant Virus Research Studies
- Herpesvirus Infections and Treatments
- Galectins and Cancer Biology
- Virology and Viral Diseases
- Neonatal and Maternal Infections
- Vibrio bacteria research studies
- Coccidia and coccidiosis research
- Corneal Surgery and Treatments
- Ion channel regulation and function
- Heat shock proteins research
- Mosquito-borne diseases and control
- Optimization and Search Problems
- RNA and protein synthesis mechanisms
- Wound Healing and Treatments
- Facility Location and Emergency Management
- Microbial Community Ecology and Physiology
- Signaling Pathways in Disease
- Risk and Safety Analysis
- Extracellular vesicles in disease
Longyan University
2016-2025
Union Hospital
2023-2024
Huazhong University of Science and Technology
2023-2024
Nantong University
2024
Shenzhen University
2024
Fujian Agriculture and Forestry University
2012-2021
Taishan Medical University
2013
Chinese Academy of Sciences
2012
Anhui Science and Technology University
2008
Suzhou University of Science and Technology
2006
Abstract Wildlife is reservoir of emerging viruses. Here we identified 27 families mammalian viruses from 1981 wild animals and 194 zoo collected south China between 2015 2022, isolated characterized the pathogenicity eight Bats harbor high diversity coronaviruses, picornaviruses astroviruses, a potentially novel genus Bornaviridae . In addition to reported SARSr-CoV-2 HKU4-CoV-like viruses, picornavirus respiroviruses also likely circulate bats pangolins. Pikas new clade Embecovirus...
Porcine circovirus 2 (PCV2) has been prevalent in swine herds China since 2002, causing severe economic loss to the pig industry. The number of live pigs southeast is > 20 million. Since information on genetic variation PCV2 Fujian province limited, objective present work was investigate epidemiological and evolutionary characteristics from 2013 2017. Of 685 samples collected 90 different 2017, 356 84 were positive for PCV2. PCV2a, PCV2b, PCV2d, PCV2e co-existed province, with PCV2d being...
Since we first reported porcine reproductive and respiratory syndrome virus 1 (PRRSV1) wild type strains in mainland China 2011, PRRSV1 infection has been detected more than 20 provinces China. During the routine investigation of epidemiology 2022, isolated a novel strain (SD1291) from an adult slaughter pig Linyi, Shandong Province. The SD1291 could only be with primary alveolar macrophages (PAMs), not Marc-145 cells. In addition, 2022 isolate higher vitro replication efficacy 2014 HLJB1...
Since the first isolation of porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) BJEU06-1 strain from a Beijing pig farm in 2006, more PRRSV-1 isolates have been identified China. In this study, we performed routine detection using 1521 clinical samples collected 12 provinces/cities February 2022 to May 2024. Only three lung severely diseased piglets January 2024 were detected as PRRSV-1-positive (0.197%, 3/1521). A (AHEU2024-2671) was successfully isolated primary alveolar...
Background: Endometritis seriously affects maternal reproductive health and fertility. Natural compounds have the characteristics of high efficiency low residue in disease treatment. We aimed to discover reveal pharmacological effects naringin, which is widely present food plants, on endometritis. Methods: Based network pharmacology, potential targets pathways naringin’s actions endometritis were predicted. Animal vivo experiments conducted examine inflammatory response lipopolysaccharides...
Although the T-cell-mediated immune response to influenza virus has been studied extensively, little information is available on direct interaction between and T-cells that pertains severe diseases in humans animals. To address these issues, we utilized BALB/c mouse model combined with primary infected A/WSN/33 investigate whether an affinity for vivo. We observed small proportions of CD4(+) CD8(+) spleen thymus expressed viral proteins mice. A significant proportion displayed expression...
Abstract Biofilm is a group of heterogeneously structured and densely packed bacteria with limited access to nutrients oxygen. These intrinsic features can allow mono-species biofilm diversify into polymorphic subpopulations, determining the overall community’s adaptive capability changing ecological niches. However, specific biological functions underlying diversification fitness adaptation are poorly demonstrated. Here, we launched monitored experimental evolution Pseudomonas aeruginosa...
Porcine parvovirus (PPV) is an important pathogen causing reproductive disorders in sows, with clinical symptoms including stillbirth, mummified fetuses, embryonic dysplasia and death, sow infertility. 7 (PPV7) a recently discovered type of PPV its widespread distribution rapid evolution has caused huge economic losses the pig industry. To investigate molecular epidemiology PPV7 Fujian Province, China, we collected 491 blood samples 72 tissue from diseased pigs large-scale farms across...
Staphylococcus aureus is a versatile pathogen that can cause wide range of infections in humans. Biofilms play crucial role the pathogenicity S. and contribute to its ability persistent chronic infections. Baohuoside I has garnered increasing recognition as natural flavonol glycoside with spectrum health-related activities. The antibacterial anti-biofilm properties have not been extensively investigated. Our study aimed assess inhibitory effects underlying mechanisms on biofilm formation...
Streptococcus agalactiae is the major cause of invasive neonatal infections and a recognized pathogen associated with various diseases in nonpregnant adults. The emergence spread antibiotic-resistant S. necessitate development novel antibacterial agent. Here, potential activities mechanisms ginkgolic acid C15:1 (GA (15:1)) from Ginkgo biloba against clinical are characterized. MIC50 MIC90 values for GA (15:1) 72 isolates were 6.25 12.5 μM, respectively. showed strong bactericidal effect both...
The aim of this study was to determine the mechanisms and molecular characterisation one strain (HPS412) Haemophilus parasuis, which exhibited high MICs antimicrobial susceptibility. A total 113 H. parasuis strains isolated from pigs suffering polyserositis, pneumonia or meningitis in China screened them for Susceptibility testing minimal inhibitory concentrations (MIC) determined fastidious medium consisting tryptone soya broth (TSB) containing 5% bovine serum 10 μg/mL NAD 96-well...
Massive hemorrhage and chronic wounds caused by bacterial infections after trauma are significant challenges in clinical practice. An ideal hemostatic wound dressing should simultaneously manage bleeding prevent also hold excellent biocompatibility bioactivities to successfully modulate immune microenvironments promote healing. In this study, a silk fibroin-based light-responsive film was demonstrated possess effective capacity of light-induced non-compressible hemostasis on liver tail
Abstract Biofilms are a hotspot of bacterial social interactions that characterized by cooperation and competition. Even mono-species biofilm would evolve diversify into polymorphic subpopulations so kins different genotypes compete for limited nutrient space. However, the specific biological functions underlying diversification competition adaptation poorly demonstrated. Here, we launched monitored experimental evolution Pseudomonas aeruginosa biofilms, finding two competition-adaptive...
Since its emergence in 2010, Tembusu virus (TMUV) has rapidly spread across poultry populations Asia, leading to substantial economic losses these areas. Here, we investigate the codon usage patterns (CUPs) underlying TMUV's adaptation and evolutionary dynamics within host environments. Phylogenetic compositional analyses consistently classify TMUV into four lineages-Clusters 1, 2, 3, ancestral TMUV-with Cluster 2 emerging as dominant lineage. Codon index (CAI) analysis reveals that this...
Parasitic infections of the South China tigers in Meihua Mountains have not been explored previously. Faeces 22 from Tiger Park were examined. Eggs ascaridoid nematodes and oocysts coccidia detected by Mini-FLOTAC assay. Morphological observation molecular characterisation carried out. The prevalence Toxascaris leonina (von Linstow, 1902) was 18% (4/22), highest egg per gram (EPG) count faeces 27,150. Cystoisospora sp. 45% (1 0/22) (OPG) 6,000. In addition, we found one nematode tiger's...
Snyder and Daskin presented p-robust models based on two classical facility location models, the PMP (P-median problem) UFLP (uncapacitated problem). We can impose a constraint dictating that relative regret in any scenario must be no greater than p, where p>0 is an external parameter. In other words, cost under each within 100(1+p)% of optimal for scenario. For small there may solutions given problem. Thus, p-robustness adds feasibility issue not present most robustness measures. this...
To investigate the molecular epidemiology of porcine parvovirus 7 (PPV7) in Fujian Province, China, 563 blood and tissue samples (491 72, respectively) were collected from suspected diseased pigs large-scale pig farms across selected areas Province 2019 to 2022. The presence PPV7 infection was determined using real-time quantitative PCR, positive subjected whole-genome amplification, sequencing, subsequent analyses including homology, phylogenetic, recombination analysis. results revealed a...