A5079454855- Catalytic Cross-Coupling Reactions
- Organoboron and organosilicon chemistry
- Catalytic C–H Functionalization Methods
- Supercapacitor Materials and Fabrication
- Asymmetric Hydrogenation and Catalysis
- Layered Double Hydroxides Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Advanced Sensor and Energy Harvesting Materials
- Synthetic Organic Chemistry Methods
- Advanced battery technologies research
- Chemical Synthesis and Characterization
- Chemical Synthesis and Analysis
- Epigenetics and DNA Methylation
- Cardiovascular Health and Disease Prevention
- Microtubule and mitosis dynamics
- Renal and related cancers
- Circular RNAs in diseases
- Surface Modification and Superhydrophobicity
- Thermal properties of materials
- Protein Degradation and Inhibitors
- Advanced Image Processing Techniques
- Icing and De-icing Technologies
- MicroRNA in disease regulation
- X-ray Diffraction in Crystallography
Tianjin University of Traditional Chinese Medicine
2023-2025
Eastern Hepatobiliary Surgery Hospital
2024
Second Military Medical University
2024
Chinese Academy of Sciences
2017-2024
University of Chinese Academy of Sciences
2019-2024
Southern University of Science and Technology
2024
Shenzhen Institutes of Advanced Technology
2024
Shanghai East Hospital
2024
Liaoning Technical University
2022-2023
Hebei University of Engineering
2022
Optically active organoboronic acids and their derivatives are an important family of target compounds in organic chemistry, catalysis, medicinal chemistry. Yet there rare asymmetric catalytic examples reported for the synthesis these via atom step economic ways. Herein, we report a chelate-directed iridium-catalyzed C(sp2)–H borylation aromatic C–H bonds directed by free amine groups. The success transformations relies on novel chiral bidentate boryl ligands (L). They can be synthesized...
The catalytic isomerization of C–C double bonds is an indispensable chemical transformation used to deliver higher-value analogues and has important utility in the industry. Notwithstanding advances reported this field, there compelling demand for a general solution that enables precise control C═C bond migration position, both cyclic acyclic systems, furnish disubstituted trisubstituted alkenes. Here, we show amounts appropriate earth-abundant iron-based complex, base boryl compound,...
Diborylation of lithiated carbamates is reported for the first time to synthesize 1,1-diboronate esters with a fully substituted benzylic center.
Interlayer spacing and structure stability of layered double hydroxides (LDHs) on their application performance in adsorption, ion exchange, catalysis, carrier, energy storage is important. The effect different interlayer anions the LDHs has been less studied, but it great significance. Therefore, based density functional theory (DFT), computational model with 10 kinds intercalated Ni3Al-A-LDHs (A = Cl-, Br-, I-, OH-, NO3-, CO32-, SO42-, HCOO-, C6H5SO3-, C12H25SO3-) four Ni R Al-Cl-LDH...
A copper-catalyzed asymmetric protoboration of both Z-β-amidoacrylonitriles and ethyl E-β-amidoacrylates using bis(pinacolato)diboron has been developed for the first time. The process tolerates a vast array substrates, delivering series stable functionalized chiral α-amino boronate esters in good yields enantioselectivities under mild reaction conditions. current method is also applicable gram-scale synthesis without erosion enantioselectivity. This work provides an attractive complementary...
Glucose metabolism plays a critical role in the development and progression of kidney renal clear cell carcinoma (KIRC). This study aimed to identify glucose metabolism-related biomarkers (GRBs) therapeutic targets for KIRC diagnosis prognosis using bioinformatics machine learning. Gene expression data from Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases, along with genes multiple sources, were analyzed. Differentially co-expressed (DCGLGs) identified through differential...
The first examples of an iron-catalyzed three-component synthesis homoallylic boronates from regioselective union bis(pinacolato)diboron, alkenyl halide (bromide, chloride or fluoride), and olefin are disclosed. Products that bear tertiary quaternary carbon centers could be generated in up to 87 % yield as single regioisomers with complete retention the stereochemistry. With cyclopropylidene-containing substrates, ring cleavage leading trisubstituted E-alkenylboronates were selectively...
Glioblastoma (GBM) is a uniformly lethal disease driven by glioma stem cells (GSCs). Here, we use chemical biology approach to unveil previously unknown GBM dependencies. By studying sulconazole (SN) with anti-GSC properties, find that SN disrupts biotin distribution the carboxylases and histones. Transcriptomic metabolomic analyses of SN-treated GSCs reveal metabolic alterations are characteristic biotin-deficient cells, including intracellular cholesterol depletion, impairment oxidative...
layered double hydroxide (LDH) as a kind of 2D layer material has swelling phenomenon. Because significantly affects the adsorption, catalysis, energy storage, and other application properties LDHs, it is essential to study interlayer spacing, structural stability, ion diffusion after swelling. In this paper, periodic computational model Ni3Al-LDH constructed, supramolecular structure, law, anion are investigated by molecular dynamics theory calculations. The results show that water...
Abstract Background miR-152-3p functions as a tumour suppressor in the progression of hepatic tumorigenesis. Herein, we further discussed prognostic significance and immune infiltration its potential gene target hepatocellular carcinoma (HCC). Methods The Cancer Genome Atlas (TCGA), Integrative Molecular Database Hepatocellular Carcinoma (HCCDB), Human Protein (HPA) Kaplan–Meier Plotter databases were used to evaluate roundabout guidance receptor 1 ( ROBO1 ) expression, prognosis...
This study presents an innovative technique to create aluminum-polydimethylsiloxane (PDMS) composite embedded with liquid metal (LM) pillars, abbreviated as (Al-PDMS-LMP). method not only allows for customized adjustment of the thermal conductivity interface material but also efficiently utilizes high advantage metal. When content is 17.53 vol %, can reach 10.9 Wm–1K–1. Moreover, addition LM pillars enhances pad softness, promoting better contact between interfaces and heat dissipation...
Metabolic reprogramming is a significant feature of tumor cells, and targeting metabolic pathways has become viable strategy for cancer therapy. Gluconeogenesis essential to glucose metabolism, with phosphoenolpyruvate carboxykinase 1 (PCK1) 2 (PCK2) as key enzymes. The roles PCK1 PCK2 in various cancers remain unclear. We conducted comprehensive overview human cancers, assessing their expression association prognosis, immunity, drug sensitivity. Prognostic relevance, synergistic effects,...
The prognosis of osteosarcoma has not been improved for decades. As radioresistance is one the major reasons, effective radiotherapy sensitization drugs need to be discovered. HOS and K7M2 cell lines were treated with disulfiram (DSF) radiation assess viability, proliferation, migration ability, apoptosis level, ROS Ca2+ cycle in vitro. A HOS-derived subcutaneous tumor mouse model was constructed evaluate growth after DSF combined radiation, Tunel assay immunohistochemistry Ki67 conducted....
Abstract The first examples of an iron‐catalyzed three‐component synthesis homoallylic boronates from regioselective union bis(pinacolato)diboron, alkenyl halide (bromide, chloride or fluoride), and olefin are disclosed. Products that bear tertiary quaternary carbon centers could be generated in up to 87 % yield as single regioisomers with complete retention the stereochemistry. With cyclopropylidene‐containing substrates, ring cleavage leading trisubstituted E ‐alkenylboronates were...
The isotopic fractionation factor and element partition coefficient can be calculated only after the geometric optimization of molecular clusters is completed. Optimization directly affects accuracy some parameters, such as average bond length, volume, harmonic vibrational frequency, other thermodynamic parameters. Here, we used improved volume variable cluster model (VVCM) method to optimize a typical oxide, quartz. We documented length relative change. Finally, extracted frequencies...
Vapor sink is an effective strategy to suppress the formation of water vapor condensation around hygroscopic materials, and consequently reduce frosting icing. However, traditionally used such as salt solutions, fibers, exhibit insufficient inhibition or pose safety concerns, corrosiveness. In this study, we highlight remarkable anti-condensation properties glycerol droplets, attributed their strong hygroscopicity. We compared capabilities droplets with commonly solutions alcohols. The...