A5102785479- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Dementia and Cognitive Impairment Research
- Alcoholism and Thiamine Deficiency
- Anesthesia and Neurotoxicity Research
- Neural and Behavioral Psychology Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Reproductive Health and Contraception
- Cardiac, Anesthesia and Surgical Outcomes
- Memory and Neural Mechanisms
- Health disparities and outcomes
- Simulation-Based Education in Healthcare
- Neuroscience and Music Perception
- Maternal and fetal healthcare
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Intramuscular injections and effects
- Orthopaedic implants and arthroplasty
- Electroconvulsive Therapy Studies
- Cerebrospinal fluid and hydrocephalus
- Intergenerational Family Dynamics and Caregiving
- Multisensory perception and integration
- Mental Health Treatment and Access
- Health, psychology, and well-being
University Medical Center Freiburg
1975-2023
University of Freiburg
2022-2023
Beth Israel Deaconess Medical Center
2023
Harvard University
1996-2023
Klinikum Stuttgart
2014-2021
NIHR Leeds Musculoskeletal Biomedical Research Unit
2019
West Chester University
2005-2019
University of Leeds
2019
Women's and Children's Hospital
2015
Evangelisches Krankenhaus Bielefeld
2007-2013
Background The cost of depression in the UK was estimated at £33.5 billion almost: adecade ago. shift to community-based management for alongside availability more accurate data have allowed these estimates be revised. Aims To calculate total adults England during 2000. Method Recorded on health service use by patients with were analysed and treating calculated. working life lost from sickness benefit claims number registered deaths depression. Results adult over £9 billion, which £370...
The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined diagnosis using these compared with the fourth (DSM-IV) in a large dataset of patients assessed related presentations.Patient data (n = 768) from six prospectively collected cohorts, clinically DSM-IV Delirium Rating Scale-Revised-98 (DRS-R98), were pooled. Post hoc application DRS-R98 item scores used to rate DSM-5 criteria. 'Strict' 'relaxed' ascertain rates determined by...
To determine the cost to NHS resulting from multiple pregnancies arising IVF treatment in UK, and compare those costs with due singleton treatment.A modelling study using data published literature national sources public domain, calculating direct diagnosis of a clinical pregnancy until end first year after birth.Academic Unit Reproductive Developmental Medicine.Theoretic core literature.The analysis was based on total annual number births an UK. Main outcome measures per singleton, twin or...
Objectives To determine whether sleep disruption at home or in hospital is an independent risk factor for postoperative delirium older adults undergoing elective surgery. Design Prospective cohort study. Setting German teaching hospital. Participants Individuals aged 65 and arthroplasty (N = 101). Measurements Preoperative questionnaires were used to assess (Pittsburgh Sleep Quality Index). Actigraphy was objectively measure the before after Delirium assessed daily surgery using Confusion...
Background and Purpose Cerebrovascular CO 2 reactivity can be assessed easily reliably by transcranial Doppler sonography. The objectives of the present study were to evaluate sex differences in cerebral specify relation between blood flow velocity. Methods circulation both middle arteries was measured bilateral sonography 60 healthy volunteers (30 men, 30 women) aged 21 58 years. End-tidal carbon dioxide tensions (P etco ) elevated with use carbogene gas (95% O , 5% ). In each subject mean...
Delirium increases morbidity, mortality and healthcare costs especially in the elderly. Serum anticholinergic activity (SAA) is a suggested biomarker for burden delirium risk, but association with cerebral cholinergic function remains unclear. To clarify this relationship, we prospectively assessed correlation of SAA quantitative electroencephalography (qEEG) power, occurrence, functional cognitive measures cross-sectional sample acutely hospitalized elderly (> 80 y) high dementia...
<i>Objectives:</i> To assess validity and interrater reliability of an operationalized German version the Confusion Assessment Method (CAM) in geriatric patients with comorbid dementia high delirium risk. <i>Design:</i> Prospective cross-sectional cohort study double CAM assessment by a medical nonmedical rater. <i>Setting:</i> Random sample frail, cognitively impaired elderly acute disease requiring hospital care. <i>Participants:</i> A total...
This paper details the application of Benner's Novice to Expert Model simulation educator knowledge, skills, and attitude for academic practice settings. Facilitator development in use methods is gaining more attention support. If continue advance as a discipline, theoretical basis needed. The provides necessary conceptual structure guide facilitator assist understanding learning trajectory. theory-based approach that defines operationalizes five stages guidance resources, educational...
Delirium in the elderly results increased morbidity, mortality and functional decline. is underdiagnosed, particularly dementia. To increase diagnostic accuracy, we investigated whether maintenance of activation assessed by EEG discriminates delirium association with dementia (D+D) from without (DP) cognitively unimpaired subjects (CU).Routine quantitative (rEEG/qEEG) additional prolonged (3 min eyes open period) were evaluated hospitalised patients acute geriatric disease. Patients assigned...
Background The cost of depression in the UK was estimated at £33.5 billion almost: adecade ago. shift to community-based management for alongside availability more accurate data have allowed these estimates be revised. Aims To calculate total adults England during 2000. Method Recorded on health service use by patients with were analysed and treating calculated. working life lost from sickness benefit claims number registered deaths depression. Results adult over £9 billion, which £370...
The World Health Organization and Centers for Disease Control Prevention no longer recommend aspiration during intramuscular (IM) injections. purpose of this study was to investigate the technique registered nurses (RNs) use IM injections incidence blood aspiration. This descriptive surveyed 164 RNs. Results noted that 74% sample continue aspirate at least 90% time. Of participants who aspirate, only 3% recommended 5 10 s. Forty percent reported having aspirated once, whereas 6 RNs (4%) ≥13...
Abstract Background The association of frailty based on the accumulation deficits with postoperative delirium (POD) has been poorly examined. We aimed to analyze this in older patients undergoing elective surgery. Methods Preoperative data was used build a 30-item index (FI) for participants PAWEL-study. Delirium defined by combination I-CAM and chart review. Using logistic regressions models we analysed between POD adjusting age, sex, smoking, alcohol consumption, education type Results...
There is still some controversy about alterations in velocity of blood flow and cerebral vasomotor reactivity intracranial arteries migraineurs during the interictal phase. By means simultaneous bilateral transcranial Doppler ultrasonography we, therefore, assessed fIow velocities cerebrovascular to carbon dioxide all three basal brain 20 phase 30 nonheadache‐prone control subjects. Mean were higher than controls on both sides, with a significant difference ( P <0.05) for right anterior...
<h3>Background:</h3> Progressive pseudorheumatoid dysplasia(PPRD) is considered as a degenerative genetic bone disorder. It caused by loss of function mutation in WNT-1 inducible signaling pathway protein-3(WISP-3)<sup>1</sup>. WISP-3 gene required for the normal cartilage and skeletal development. The patients are at birth start developing symptoms around 3-6 years age<sup>2</sup>. disease characterised stiffness, pain, deformity due to enlargement ends short long bones. Often, such...
Abstract Objectives Quantitative EEG can monitor changes in brain function during development and may help to understand developmental disorders. However, current EEG‐databases are primarily based on standardized frequency bands which disregard age‐related alpha peak (PF) therefore complicate the interpretation of spectral estimates theta range. Methods We used a two point longitudinal design order analyze intraindividual 40 healthy children adolescents with age (T 1 : 6–18 years; interval...
To calculate the cost of an unintended pregnancy in 2011 and use this a cost-effectiveness model comparing ulipristal acetate (UPA) with levonorgestrel (LNG) for emergency hormonal contraception (EHC).Retrospective analysis published data sources model.Women presenting primary care England EHC within 24 or 72 h unprotected sexual intercourse (UPSI).EHC either LNG (1.5 mg) UPA (30 mg).The outcome measure is number direct indirect costs pregnancy. The secondary consequence pregnancy:...