A5015554240- Mosquito-borne diseases and control
- Family Support in Illness
- Acute Lymphoblastic Leukemia research
- Neuroinflammation and Neurodegeneration Mechanisms
- Parasitic Diseases Research and Treatment
- Childhood Cancer Survivors' Quality of Life
- Mentoring and Academic Development
- Management of metastatic bone disease
- Pancreatic and Hepatic Oncology Research
- Advanced Nanomaterials in Catalysis
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Bone fractures and treatments
- PI3K/AKT/mTOR signaling in cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Sarcoma Diagnosis and Treatment
- Diversity and Career in Medicine
- Tryptophan and brain disorders
- HIV Research and Treatment
University of Miami
2019-2024
Lahey Hospital and Medical Center
2024
University of Arizona
2023
Phoenix Children's Hospital
2023
Cancer cells are known to be glycolytic, driving increased glucose consumption and its conversion lactate. This process modulates the tumor microenvironment (TME). In TME, glycolytically activated immune often become anergic, leading an increase in checkpoint proteins such as programmed cell death protein-1 (PD-1) cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4). Most glycolytic inhibitors not only inhibit glycolysis of cancer but also cells. Therefore, using a nanoparticle-delivered...
The spread of Zika virus (ZIKV) infection across the USA and various countries in last three years will not only have a direct impact on U.S. health care system but has caused international concerns as well. ultimate ZIKV remains to be understood. Currently, there are no therapeutic or vaccine options available protect those infected by ZIKV. drug ivermectin (IVM) was found viable agent for prevention transmission Ivermectin is unstable presence water does remain adequate concentration human...
Human neurotropic immunodeficiency virus (HIV) ingress into the brain and its subsequent replication after infection results in viral reservoirs brain. The infected cells include microglia, perivascular macrophages, astrocytes. HIV-associated neurocognitive disorders (HAND) affect glial by activating microglia macrophages through neuroinflammation, as well astrocytes mitochondrial dysfunctions onset of oxidative stress, impairing ability these to engage neuroprotection. Furthermore, risk...
There is urgent therapeutic need for COVID-19, a disease which there are currently no widely effective approved treatments and the emergency use authorized drugs do not result in significant widespread patient improvement. The food drug administration-approved ivermectin has long been shown to be both antihelmintic agent potent inhibitor of viruses such as Yellow Fever Virus. In this study, we highlight potential packaged an orally administrable nanoparticle that could serve vehicle deliver...
Since its discovery in 1965, the inorganic drug cisplatin has become a mainstay of cancer therapies and inspired many platinum (Pt)-based compounds to solve various issues toxicity limitations associated with original cisplatin. However, these drugs/prodrugs continue be plagued by an array side effects, limited circulation, half-life off-target effects. To this issue, we have constructed platinum-based prodrugs on Pt(IV) skeleton, which provides more favorable geometry hydrophobicity, easier...
BACKGROUND: Tucatinib is a tyrosine kinase inhibitor currently used in salvage therapy for human epidermal growth factor receptor 2 (HER2)-positive breast and colorectal cancer. The use of tucatinib alone or combination with ado-trastuzumab emtansine (T-DM1) the treatment advanced HER2-positive cancers rapidly expanding. OBJECTIVE/METHODS: We report case 66-year-old female who presented to dermatology clinic one-year history widespread telangiectasias that began after initiation chemotherapy...
The "leaky pipeline" of women in science, technology, engineering, and mathematics (STEM), which is especially acute for academic mothers, continues to be problematic as face continuous cycles barriers obstacles advancing further their fields. severity prevalence the COVID-19 pandemic both highlighted exacerbated unique challenges faced by female graduate students, postdocs, research staff, principal investigators because lockdowns, quarantines, school closures, lack external childcare,...
As the COVID-19 pandemic has continued to spread, studies have shown that hospitalized patients are at significant risk for developing acute kidney injury (AKI), which can cause increased morbidity, need dialysis treatment, chronic diseases, and even death. In this paper, we present a proof-of-concept study utilization of combination therapeutic-loaded dual-targeted biodegradable nanoparticles (NPs) treat concurrent AKI in by delivering therapeutics across gut epithelial barrier kidney,...
Background While racial disparities in the clinical outcomes of hematopoietic stem cell transplant (HSCT) patients have been explored, quality life (QoL) during readjustment phase after has yet to be investigated pediatric patients. The objective this study was examine role patient race QoL at least two years HSCT. Procedure We conducted a retrospective chart review under 21 age diagnosis that received an allogeneic our institution between January 2007 and December 2017. Patient assessed...
e16194 Background: Cholangiocarcinoma (CCA) is an aggressive cancer with a poor prognosis. However, next-generation sequencing (NGS) of tumors and new mutation-targeted therapies have the potential to greatly improve treatment outcomes while reducing systemic toxicities traditional chemotherapy. In this study, we examined clinical characteristics, use NGS profiling in diverse South Florida population CCA patients identify mutations as therapeutic targets. Methods: We included treated at...
While racial disparities in the clinical outcomes of hematopoietic stem cell transplant (HSCT) patients have been explored, quality life (QoL) during re-adjustment phase after are yet to be investigated pediatric patients. The objective this study was examine role patient race QoL at least 2 years HSCT.We conducted a retrospective chart review under 21 age diagnosis who received an allogeneic our institution between January 2007 and December 2017. Patient assessed using Pediatric...