A5113282589- Hematopoietic Stem Cell Transplantation
- Biochemical and Molecular Research
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Macrophage Migration Inhibitory Factor
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood disorders and treatments
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
The Ohio State University
2023-2025
The Ohio State University Wexner Medical Center
2024
Acute graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation (allo-HCT). Using preclinical mouse models disease, previous work in our laboratory has linked microRNA-155 (miR-155) to the development acute GVHD. Transplantation donor T cells from miR-155 host gene (MIR155HG) knockout mice prevented GVHD multiple murine while maintaining critical graft-versus-leukemia (GVL) response, necessary for relapse prevention. In this study, we used...
Abstract Acute graft-versus-host disease (GVHD) is a donor T cell driven complication and the leading cause of non-relapse mortality in patients receiving an allogeneic hematopoietic transplantation (allo-HCT). Allogeneic cells eradicate residual leukemia prevent relapse via graft-versus-leukemia (GVL) effect are critical for responding against opportunistic infections post-transplant. Current regimens successful preventing GVHD broadly immunosuppressive come at cost increased risk and/or...
Head and neck squamous cell carcinoma (HNSCC) is a significant public health concern worldwide. Immunomodulatory targets in the HNSCC tumor microenvironment are crucial to enhance efficacy of immunotherapy. Macrophage migration inhibitory factor (MIF) pro-inflammatory cytokine that has been linked poor prognosis many cancers, but mechanistic role MIF remains unclear. Using murine orthotopic oral cancer model Mif