A5060984410- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- COVID-19 Impact on Reproduction
- Blood groups and transfusion
University of Alberta
2022-2024
Health jurisdictions have seen a near-disappearance of respiratory syncytial virus (RSV) during the first year coronavirus disease 2019 (COVID-19) pandemic. Over this corresponding period, we report reduction in RSV antibody levels and live neutralization sera from women childbearing age infants between May to June 2020 February 2021, British Columbia (BC), Canada. This supports that immunity against is relatively short-lived maintaining optimal requires repeated maternal viral exposure....
Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization. All current RSV therapeutics, including antibody prophylaxis and adult vaccination, target fusion glycoprotein (RSV-F). The seven neutralization sites on RSV-F are highly conserved infrequently mutate. Here, we show that a single amino acid mutation at position 305 in significantly alters antigenic recognition binding reduces susceptibility to neutralizing antibodies. In an vitro evolution assay, L305I occurs...
Abstract Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization. All current available RSV therapeutics including antibody prophylaxis and adult vaccination target fusion glycoprotein (RSV-F).The seven neutralization sites on RSV-F are highlyconserved infrequently mutated. Here, we show that asingle amino acid mutation at position 305 in significantly alters antigenic recognition binding changes susceptibility to neutralizing antibodies. In an vitro evolution assay,...
RSV is the leading cause of infant hospitalizations and a significant paediatric geriatric morbidity worldwide. Recently, we reported that insulin-like growth factor 1 receptor (IGF1R) was for respiratory syncytial virus (RSV) in airway epithelial cells activation IGF1R recruited coreceptor, nucleolin (NCL), to cell surface. Cilia mucus line airways pose barrier viral bacterial infection. The cortical actin cytoskeleton has been shown by others mediate entry, so studied roles receptors...
Studies have linked respiratory syncytial virus (RSV) antibody-mediated phagocytosis and complement deposition to severe RSV infection in humans. This study shows waning of these antibody functions women childbearing age 2020-2021 during the implementation COVID-19 mitigation measures, absence circulation. These could be explored as correlates protection against disease.
<title>Abstract</title> Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization. All current available RSV therapeutics, including antibody prophylaxis and adult vaccination, target fusion glycoprotein (RSV-F). The seven neutralization sites on RSV-F are highly conserved infrequently mutated. Here, we show that a single amino acid mutation at position 305 in significantly alters antigenic recognition binding reduces susceptibility to neutralizing antibodies. In an...
ABSTRACT Studies have linked reduced respiratory syncytial virus-specific Fc-mediated phagocytic function and complement deposition to more severe infection. This study shows a loss of these functions during the first year COVID-19 pandemic. These findings corroborate other data supporting general waning RSV antibody in absence viral circulation.