A5103001185- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Hippo pathway signaling and YAP/TAZ
- Liver physiology and pathology
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
McGill University Health Centre
2021-2023
McGill University
2021
Vessel co-option is correlated with resistance against anti-angiogenic therapy in colorectal cancer liver metastases (CRCLM). co-opting lesions are characterized by highly motile cells that move toward and along the pre-existing vessels surrounding nonmalignant tissue co-opt them to gain access nutrients. To sinusoidal vessels, vessel must displace hepatocytes occupy their space. However, mechanisms underlying this displacement unknown. Herein, we examined involvement of apoptosis,...
Abstract Vessel co-option in colorectal cancer liver metastases (CRCLM) has been recognized as one of the mechanistic pathways that contribute to resistance against anti-angiogenic therapy. In vessel co-opted CRCLM lesions, cells are highly motile move toward and along pre-existing sinusoidal vessels hijack them gain access nutrient. The movement is accompanied by replacement hepatocytes. However, molecular mechanisms which this occurs unclear yet. To examine involvement apoptosis...
Metastasis is the principal cause of cancer treatment failure and an area dire diagnostic needs. Colorectal metastases to liver (CRCLMs) are predominantly classified into desmoplastic replacement based on their histological growth patterns (HGPs). Desmoplastic responds well current treatments, while HGP has a poor prognosis with low overall survival rates.
Abstract Vessel co-option in colorectal cancer liver metastases (CRCLM) has been recognized as one of the mechanistic pathways resistance against anti-angiogenic therapy. The cells are highly motile co-opted lesions, which move toward and along pre-existing sinusoidal vessels hijack them to gain access nutrient. movement is accompanied by displacement hepatocytes. However, molecular mechanisms underlying this unclear yet. To examine whether apoptosis involved hepatocytes we performed...