A5026937185- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
- Macrophage Migration Inhibitory Factor
- Cell Adhesion Molecules Research
- Nuclear Receptors and Signaling
- Connective Tissue Growth Factor Research
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Bone Metabolism and Diseases
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
Duke University
1994-2024
Duke Medical Center
1995
Duke University Hospital
1995
The transforming growth factor beta s (TGF-beta s) are a group of multifunctional factors which inhibit cell cycle progression in many types. TGF-beta-induced arrest has been partially attributed to the regulatory effects TGF-beta on both levels and activities G1 cyclins their kinase partners. these kinases negatively regulated by number small proteins, p21 (WAF1, Cip1), p27Kip1, p16, p15INK4B, that physically associate with cyclins, cyclin-dependent kinases, or cyclin-Cdk complexes....
Conventional dendritic cells (DCs) are essential mediators of antitumor immunity. As a result, cancers have developed poorly understood mechanisms to render DCs dysfunctional within the tumor microenvironment (TME). After identification CD63 as specific surface marker, we demonstrate that mature regulatory (mregDCs) migrate tumor-draining lymph node tissues and suppress DC antigen cross-presentation in trans while promoting T helper 2 cell differentiation. Transcriptional metabolic studies...
The role of transforming growth factor (TGF) beta type II receptor in reversing the malignant phenotype human breast cancer MCF-7 cells was examined. were insensitive to TGF 1 and expressed undetectable levels cell surface I (RI) (RII) by cross-linking with 125I-TGF 1. Stable transfection a RII expression vector yielded 3 transfectants varying exogenous mRNA protein levels. Expression also increased binding RI all clones. Proliferation RII-positive clones inhibited dose-dependent manner,...
Inhibition of cell growth by type beta transforming factor (TGF-beta) occurs in mid-G1 and is associated with decreased G1 cyclin-dependent kinase activity maintenance the retinoblastoma tumor suppressor protein Rb an underphosphorylated, growth-suppressive state. A variety recent experiments suggest that a functional target E2F transcription factor. In addition, effects TGF-beta can be overcome expression viral oncogene products dissociate from Rb-related polypeptides. These results...
The dwarfin protein family has been genetically implicated in transforming growth factor beta (TGF-beta)-like signaling pathways Drosophila and Caenorhabditis elegans. To investigate the role of these proteins mammalian pathways, we have isolated studied two murine dwarfins, dwarfin-A dwarfin-C. Using antibodies against dwarfin-C, show that dwarfins an immunogenically related protein, presumably also a dwarfin, are phosphorylated time- dose-dependent manner response to TGF-beta. Bone...
<h3>Background</h3> Dendritic cells (DCs) are essential mediators of anti-tumor immunity and necessary for effective checkpoint blockade responses, however within the tumor microenvironment (TME), dysfunctional DCs develop that promote tolerance.<sup>1–3</sup> We have recently discovered tumor-derived lactate activates SREBP2 in TME, promoting development pro-tolerogenic mature regulatory (mregDCs).<sup>4</sup> DC-restricted silencing suppressed mregDC inhibited progression <i>in vivo</i>....