A5020538537- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Legume Nitrogen Fixing Symbiosis
- RNA and protein synthesis mechanisms
- Microbial infections and disease research
- CRISPR and Genetic Engineering
- Evolution and Genetic Dynamics
Durham University
2022-2024
Bacteria are under constant assault by bacteriophages and other mobile genetic elements. As a result, bacteria have evolved multitude of systems that protect from attack. Genes encoding bacterial defence mechanisms can be clustered into 'defence islands', providing potentially synergistic level protection against wider range assailants. However, there is comparative paucity information on how expression these controlled. Here, we functionally characterize transcriptional regulator, BrxR,...
Bacteriophages (phages) outnumber bacteria ten-to-one and cause infections at a rate of 10
Bacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) recognize and methylate 6 bp non-palindromic motifs within the host genome, prevent replication non-methylated phage DNA encodes these same motifs. How BREX recognizes cognate has not been fully understood. We characterised from pathogenic Salmonella generated first X-ray crystallographic structures conserved protein, PglX. The PglX N-terminal...
Abstract Bacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) recognise and methylate 6 bp non-palindromic motifs within the host genome, prevent replication non-methylated phage DNA encodes these same motifs. How BREX recognises cognate has not been fully understood. In this study we characterise from pathogenic Salmonella present X-ray crystallographic structures conserved protein, PglX. The PglX...
A bstract Bacteria are under constant assault by bacteriophages and other mobile genetic elements. As a result, bacteria have evolved multitude of systems that protect from attack. Genes encoding bacterial defence mechanisms can be clustered into “defence islands”, providing potentially synergistic level protection against wider range assailants. However, there is comparative paucity information on how expression these controlled. Here, we functionally characterise transcriptional regulator,...