A5022422935- Colorectal Cancer Treatments and Studies
- Pharmacy and Medical Practices
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Neutropenia and Cancer Infections
- Cancer Treatment and Pharmacology
- Pharmaceutical Practices and Patient Outcomes
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Statistical Methods in Clinical Trials
- Neuroendocrine Tumor Research Advances
- Multiple Myeloma Research and Treatments
- Hepatitis B Virus Studies
- Safe Handling of Antineoplastic Drugs
- HER2/EGFR in Cancer Research
- Chemokine receptors and signaling
- Blood disorders and treatments
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical studies and practices
- Chemotherapy-related skin toxicity
- Diabetes and associated disorders
- Advanced Breast Cancer Therapies
- Nutrition, Genetics, and Disease
National Center for Global Health and Medicine
2022-2024
National Hospital Organization
2016-2023
Tokyo Medical Center
2016-2023
Center for Global Health
2023
Toho University
2020-2021
University of Toyama
2012
Shizuoka Cancer Center
2008-2010
The University of Tokyo
1999-2009
Bunkyo University
2009
Tohoku Medical and Pharmaceutical University
2003
Docetaxel has been reported to show promising anti-tumour activity in pancreatic ductal cancer (PC). This study was conducted evaluate the and toxicity of moderate-dose (60 mg m−2) docetaxel Japanese chemo-naive patients with measurable metastatic PC. The had a performance status 0–2. They received intravenously over 1- 2-h period without any premedication for hypersensitivity reactions. treatment repeated every 3–4 weeks dose adjustments based on toxic effects observed. Twenty-one were...
Curcumin has been shown to have potent anti-metastatic activity, however, its mechanism of action is still unclear. Here, we analyzed the using hepatocellular carcinoma, CBO140C12 cells. Daily oral administration curcumin suppressed intrahepatic metastasis in a dose-dependent manner, whereas growth implanted tumors was not affected. We next examined effect on several metastatic properties vitro. inhibited invasion tumor cells through Matrigel-coated filters and production MMP-9. In addition,...
Due to their chemoattractant properties stimulating the accumulation of infiltrating immune cells in tumors, chemokines are known have antitumor effects. Fractalkine, a unique CX3C chemokine, is expressed activated endothelial cells, while its receptor, CX3CR1, cytolytic such as natural killer monocytes and some CD8+ T cells. The biological cancer affected by implantation organ differences systems, requiring orthotopic organs an vivo experiment. To develop new therapy strategies for lung...
Abstract Background Genetic polymorphisms of molecules are known to cause individual differences in the therapeutic efficacy anticancer drugs. However, date, germline mutations (but not somatic mutations) for drugs have been adequately studied. The objective this study was investigate association between gemcitabine metabolic and transporter genes with carbohydrate antigen 19‐9 (CA 19‐9) response (decrease ≥50% from pretreatment level at 8 weeks) overall survival (OS) patients metastatic...
Abstract #3132 Introduction: Treatment with trastuzumab (H) is a standard therapy for the patients HER2 positive metastatic breast cancer (MBC) and both combination H chemotherapy (CT) alone are very popular. However, it unknown which better; sequential followed by of CT at disease progression or as first-line therapy. Therefore, we conducted phase III randomized trial compared them in MBC.
 Methods: Eligible were MBC (pts) measurable tumour based on RECIST, ECOG Performance...
The importance of compliance with National Comprehensive Cancer Network (NCCN) guidelines for preventing varicella-zoster virus reactivation (VZVr) in multiple myeloma (MM) a clinical setting has not been well investigated.We retrospectively studied the characteristics and outcomes 118 patients MM treated proteasome inhibitors.Thirty-nine episodes VZVr were observed 37 (VZVr group). proportion prophylactic antiviral prescriptions prophylaxis based on NCCN Clinical Practice was 76% 30% group,...
651 Background: In the GENESECT study, we examined relationships between gemcitabine (GEM) metabolism-related germline genetic polymorphisms (GPs) and treatment efficacy safety. However, no significant GPs were found because approximately 70% of patients treated with nab-paclitaxel, which has a different metabolic process than GEM. present subanalysis including only GEM monotherapy was performed. Methods: Of 159 analyzed in selected. The endpoints carbohydrate antigen 19-9 (CA19-9) response...
The aim of this prospective study was to examine the issues these items evaluate possibility their application clinical practice. This survey performed on pharmacists 14 hospitals. number confirmation 345 and 375 in control group recommended item group, respectively. mean time required for completing a regimen check (±standard deviation) 4 minutes seconds (±1 minute 50 seconds) 6 18 7 Among items, that confirmed 12.4 18.6 doubt inquiries higher than (41 vs. 27 cases). related dosage,...
Abstract #4103 Background: Evidence suggests that anthracycline-containing regimens can be excluded in some patients(pts) with operable breast cancer. It is also suggested docetaxel (D) more effective than paclitaxel (P) metastatic cancer (BC) pts.
 Methods: Eligibility included axillary lymph node positive BC age less 70 years old. Pts were randomized to receive either AC(doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2) every(q) 3 weeks(wks) x 4 followed by P 175 q3 wks...
Although generic anti-tumor agents are in wide clinical use, they have not all cases been shown to be equivalent the original after preparation. In present study, and docetaxel formulations were compared with respect stability when prepared as a non-alcoholic solution for use. When formulation was diluted physiological saline make preparation, concentration decreased time, whereas no such decrease occurred preparation of made similar manner. With both formulations, time found dilution 5%...
Background/Aim: Gastrointestinal toxicity is common in patients receiving therapy of ixazomib with lenalidomide and low-dose dexamethasone (IRd) for relapsed/refractory multiple myeloma. Here, we investigated the safety effectiveness dosing schedules. Patients Methods: We retrospectively evaluated 17 consecutive treated IRd (10 on dose-escalation strategy (2.3 mg starting dose); seven standard dose). Results: The incidence grade 3 or more haematological 2 non-haematological adverse events...
Background: Reliable exposure control measures are needed to avoid occupational exposures from hazardous drugs. However, there is little information on blister packages concerning exposure. We investigated the contamination and methods of lenalidomide. Materials Methods: Nine facilities involved with RevMate program (the Japanese REMS program) participated in this study. Blister (10 capsules/ sheet, no cuts) were collected each institution after administration 5-mg Revlimid capsules....