A5103115415- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- Asymmetric Hydrogenation and Catalysis
- Crystallization and Solubility Studies
- Synthesis of Indole Derivatives
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Synthetic Organic Chemistry Methods
- Sulfur-Based Synthesis Techniques
- Medical Imaging and Pathology Studies
- Oxidative Organic Chemistry Reactions
- Synthesis and Catalytic Reactions
- Organic and Inorganic Chemical Reactions
- Gallbladder and Bile Duct Disorders
- Catalytic Alkyne Reactions
- Chemical Synthesis and Reactions
Guangxi University
2025
Guangxi Medical University
2023-2025
Sichuan University
2019-2024
Chinese PLA General Hospital
2024
China University of Petroleum, Beijing
2017
A novel C(sp3)–H bond arylation of tetrahydroisoquinoline (THIQ) derivatives with Knochel-type arylzinc reagents has been developed. In the presence MgCl2, readily reacted THIQ under oxidative conditions, affording a wide range potentially biologically active compounds in good yields. Moreover, developed method can tolerate variety sensitive functional groups such as an ester group.
Herein, a one-pot domino catalyzed three-component process is described, which initiated by palladium/zinc cooperatively cycloaddition between trimethylenemethane (TMM) and unactivated alkyl/aryl imines, followed isomerization Zn(OTf)2-catalyzed DDQ oxidation, furnishing valuable substituted pyrroles. We disclose that the cooperative catalysis affords dual-Zn(OTf)2-stabilized azapalladacycle, wherein Pd–N bond polarized Zn(OTf)2, facilitating unique outer-sphere allylic amination. Moreover,...
Presented herein is a palladium-catalyzed asymmetric (3 + 2) annulation reaction between 1,3-dienes and 2-formylarylboronic acids, proceeding in cascade vinylogous addition Suzuki coupling process. Both electron-neutral electron-deficient are compatible under similar catalytic conditions, distinct regioselectivity observed via functional-group control of 1,3-diene substrates. A collection 1-indanols with dense functionalities constructed stereoselectively.
A relay catalytic protocol using pyrrolidine and palladium catalysis has been developed for asymmetric synthesis of 1,3-diamine derivatives from 3-substituted 1,3-dienes, sulfuric diamide, aldehydes. This one-pot, three-component reaction features the advantages a high atom step economy operational simplicity, providing an efficient straightforward access to valuable 1,3-diamines incorporating quaternary tertiary stereogenic centers with moderate good enantioselectivity.
Under the catalysis of Lewis bases, cyclic enones bearing an α-(2-furyl) motif can undergo remote Friedel-Crafts reaction with electrophilic reagents via a HOMO-activation strategy, proceeding in formal vinylogous Rauhut-Currier or Morita-Baylis-Hillman-type pattern. Moreover, even less reactive α-(2-benzofuranyl)-substituted cyclopeten-2-ones be similarly HOMO-raised and furnish [4 + 2] products alkylidenemalononitriles cascade Friedel-Crafts/Michael addition process.
Abstract The Rauhut‐Currier reaction generally employs α,β‐unsaturated carbonyl compounds and nitroalkenes as the substrates. Here we develop an enantioselective formal [4+2] annulation reaction, which is initiated by intermolecular cross between electron‐deficient ortho ‐formyl‐styrenes 2‐benzoyl‐acrylonitriles catalyzed L ‐phenylglycine‐derived phosphine, followed a cascade aldol/acyl transfer/elimination process. A series of enantioenriched dialin frameworks with unusual exo ‐double bond...
A Pd-catalyzed chemodivergent cyclization strategy of TMM with formyl cinnamates by regulating solvents and cocatalysts is proposed, affording hexahydrocyclopenta[ a ]inden-8-ols, tetrahydro-2 H -indeno[1,2- b ]furans aryl cyclopentenes in good yields.