A5000319110- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Advanced biosensing and bioanalysis techniques
- Hepatitis C virus research
University of Liverpool
2021-2024
Xi’an Jiaotong-Liverpool University
2021-2024
Abstract Acquired platinum resistance poses a significant therapeutic impediment to ovarian cancer patient care, accounting for more than 200,000 deaths annually worldwide. We previously identified that overexpression of the antioxidant superoxide dismutase 1 ( SOD1 ) in is associated with platinum-resistant phenotype via conferring oxidative stress against compounds. further demonstrated enzymatic inhibition using small-molecule inhibitors or silencing RNA interference (RNAi) increased...
ABSTRACT Chronic hepatitis B virus (HBV) remains to be the most common risk factor of hepatocellular carcinoma (HCC). While previous work has primarily focussed on understanding direct and indirect mechanisms Hepatitis X protein (HBx)‐mediated hepatocarcinogenesis, from genetic epigenetic perspectives, its influence RNA modification mediated onset liver malignancies is less well understood. This study explored role HBV‐encoded HBx in altering m6A methylome profile implications pathogenesis...