A5057561909- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Biosimilars and Bioanalytical Methods
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- SARS-CoV-2 and COVID-19 Research
University Hospitals Birmingham NHS Foundation Trust
2023-2025
Queen Elizabeth Hospital Birmingham
2023
Leicester Royal Infirmary
2020
CAR T-cell manufacturing failure (MF) is a situation where the process fails to yield product or results in one which out-of-specification (OOS). We conducted multicentre retrospective review of factors contributing MF and patient outcomes. Of 981 large B-cell lymphoma (LBCL) patients approved for therapy, 38 (3.87%) had MF. Eleven received delayed infusion with in-specification (delayed-infused) following 21 remanufacturing attempts. OOS was infused 13 (OOS-infused), 14 were not infused....
Background: Bone marrow transplantation (BMT) is a unique immunosuppressed state, and the consequences of infection are often severe. We hypothesized that disruption faecal microbiota (such as with use broad spectrum antibiotics) may predispose to gastrointestinal related sepsis post bone transplantation. Methods: reviewed laboratory data from all BMT patients between January 2016 August 2018 recorded presence bacteraemia. matched these controls no then antibiotic exposure in immediate...