A5002386632- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Bioactive Natural Diterpenoids Research
- Biochemical and Structural Characterization
- Marine Invertebrate Physiology and Ecology
- Lipid Membrane Structure and Behavior
Universidad Nacional Autónoma de México
2022-2024
Abstract Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions similar and dissimilar antigens, making them versatile tools for the treatment e.g., infectious diseases animal envenomations. However, these biotherapeutics are complicated to develop due their nature. In this work, we describe application various strategies discovery cross-neutralizing nanobodies against key toxins in coral snake venoms using phage display technology. We prepare two...
Within Neotropical pit-vipers, the Mexican/Central-American clade consisting of Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium is a wide-ranging, morphologically ecologically diverse group snakes. Despite their prevalence, little known functional aspects venoms. This study aimed to fill knowledge gap regarding coagulotoxic effects examine potential different therapeutic approaches. As general trait, venoms were shown be anticoagulant but underpinned by biochemical actions....
Background Each year, 3,800 cases of snakebite envenomation are reported in Mexico, resulting 35 fatalities. The only scientifically validated treatment for snakebites Mexico is the use antivenoms. Currently, two antivenoms available market, with one developmental phase. These antivenoms, produced horses, consist F(ab’) 2 fragments generated using venoms from various species as immunogens. While previous studies primarily focused on neutralizing venom Crotalus species, our study aims to...