A5106658901- Enzyme Structure and Function
- Bacterial Genetics and Biotechnology
- Protein Structure and Dynamics
- Protein Tyrosine Phosphatases
- Gut microbiota and health
- Probiotics and Fermented Foods
- Biochemical and Molecular Research
Brandeis University
2024-2025
The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. serine/threonine phosphatase RsbU initiates B. subtilis upon binding a partner protein (RsbT) that released from sequestration by environmental stresses. We report RsbT activates inducing otherwise flexible linkers form short coiled-coil dimerizes and domains. Importantly, we present evidence related dimers diverse...
The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. serine/threonine phosphatase RsbU initiates B. subtilis upon binding a partner protein (RsbT) that released from sequestration by environmental stresses. We report RsbT activates inducing otherwise flexible linkers form short coiled-coil dimerizes and domains. Importantly, we present evidence related dimers diverse...
The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. serine/threonine phosphatase RsbU initiates B. subtilis upon binding a partner protein (RsbT) that released from sequestration by environmental stresses. We report RsbT activates inducing otherwise flexible linkers form short coiled-coil dimerizes and domains. Importantly, we present evidence related dimers diverse...
How protein phosphatases achieve specificity for their substrates is a major outstanding question. PPM family serine/threonine are widespread in bacteria and eukaryotes, where they dephosphorylate target proteins with high degree of specificity. In bacteria, control diverse transcriptional responses by dephosphorylating anti-anti-sigma factors the STAS domain family, exemplified Bacillus subtilis SpoIIE, which controls cell-fate during endospore formation, RsbU, initiates general stress...
The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. serine/threonine phosphatase RsbU initiates B. subtilis upon binding a partner protein (RsbT) that released from sequestration by environmental stresses. We report RsbT activates inducing otherwise flexible linkers form short coiled-coil dimerizes and domains. Importantly, we present evidence related dimers diverse...
Abstract How protein phosphatases achieve specificity for their substrates is a major outstanding question. PPM family serine/threonine are widespread in bacteria and eukaryotes, where they dephosphorylate target proteins with high degree of specificity. In bacteria, control diverse transcriptional responses by dephosphorylating anti-anti-sigma factors the STAS domain family, exemplified B. subtilis SpoIIE, which controls cell-fate during endospore formation, RsbU, initiates General Stress...