A5029204005- Cellular Mechanics and Interactions
- Elasticity and Material Modeling
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- X-ray Diffraction in Crystallography
- Connective tissue disorders research
- Crystallization and Solubility Studies
- Blood properties and coagulation
- Cardiomyopathy and Myosin Studies
W. M. Keck Foundation
2023-2024
Yale University
2023-2024
Melinta Therapeutics (United States)
2018
Tissue mechanical properties are determined mainly by the extracellular matrix (ECM) and actively maintained resident cells. Despite its broad importance to biology medicine, tissue homeostasis remains poorly understood. To explore cell-mediated control of stiffness, we developed mutations in mechanosensitive protein talin 1 alter cellular sensing ECM. Mutation a site between rod-domain helix bundles R1 R2 increased cell spreading tension exertion on compliant substrates. These promote...
Abstract It is widely believed that tissue mechanical properties, determined mainly by the extracellular matrix (ECM), are actively maintained. However, despite its broad importance to biology and medicine, homeostasis poorly understood. To explore this hypothesis, we developed mutations in mechanosensitive protein talin1 alter cellular sensing of ECM stiffness. Mutation a novel site between rod domain helix bundles 1 2 (R1 R2) shifted stiffness curves, enabling cells spread exert tension on...