A5002786512- Virology and Viral Diseases
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Electromagnetic Fields and Biological Effects
- Synthesis and biological activity
- Cytomegalovirus and herpesvirus research
- Ultrasound and Hyperthermia Applications
- Viral Infections and Immunology Research
- Pharmacological Effects of Natural Compounds
- Wireless Body Area Networks
- Immunodeficiency and Autoimmune Disorders
- Ammonia Synthesis and Nitrogen Reduction
- Catalytic Processes in Materials Science
- Immune Response and Inflammation
- Blood properties and coagulation
- Microwave-Assisted Synthesis and Applications
- Natural Products and Biological Research
- Microfluidic and Capillary Electrophoresis Applications
- Immunotherapy and Immune Responses
- Poxvirus research and outbreaks
- Fungal Plant Pathogen Control
Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
2023
University of Kaiserslautern
2023
Medical University of Warsaw
1977-1990
Rega Institute for Medical Research
1975-1978
KU Leuven
1976-1978
Łukasiewicz Research Network - Institute of Aviation
1975
Slovak Academy of Sciences
1974
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
1974
Institute of Virology of the Slovak Academy of Sciences
1974
An experimental model of herpetic infection based on intranasal challenge 12-day-old mice with herpes simplex virus (type 1) has been developed for assessment the efficacy a variety antiviral compounds clinical potential: cytosine arabinoside, adenine iododeoxyuridine, ribavirin, chloriteoxidized oxyamylose, polyriboinosinic-polyribocytidylic acid, and interferon. The employed is reminiscent encephalitis in humans both portal entry (nasopharyngeal cavity) mode transmission (nerve route) to...
Mice infected intravenously with vaccinia virus develop characteristic lesions over the entire tail surface. This experimental infection presents a highly sensitive and reliable model for evaluating antivaccinia activity of antiviral compounds. Ara-C (1 -β-D-arabinofuranosylcytosine), ribavirin (1-β-D-ribofuranosyl-1,2,4-tria-zole-3-carboxamide), IUdR (5-iodo-2′-deoxyuridine) as well two novel analogs IUdR, EtUdR (5-ethyl-2′-deoxyuridine), NCSUdR (5-thiocyanato-2′-deoxyuri-dine), were found...
Dimedone and its derivates are used as selective probes for the nucleophilic detection of sulfenic acids in biological samples. Qualitative analyses suggested that dimedone also reacts with cyclic sulfenamides. Furthermore, under physiological conditions, must compete highly concentrated nucleophile glutathione. We therefore quantified reaction kinetics a sulfenamide model peptide glutathione peroxiredoxin presence or absence show is stabilized at lower pH it dimedone. While reactions...
We investigate small tantalum clusters Tan+, n = 2–4, for their capability to cleave N2 adsorption spontaneously. utilize infrared photon dissociation (IR-PD) spectroscopy of isolated and size selected under cryogenic conditions within a buffer gas filled ion trap, we augment our experiments by quantum chemical simulations (at DFT level). All Tan+ clusters, seem efficiently. confirm extend previous study ambient on Ta2+ cluster [Geng et al., Proc. Natl. Acad. Sci. U. S. A. 115, 11680–11687...
Mice bearing sarcoma 180 tumors were irradiated by 3000-MHz microwave at a power density of 40 mW/cm/sup 2/ for 2 h daily during 14 consecutive days. The irradiation resulted in an increase rectal temperature 3-4/spl deg/C. Hyperthermal treatment was started on the second day after tumor-cell transplantation. Some animals also received injections polyhiboinosinic acid-polyribocytidylecacid (poly I-poly C), mu g/g, or mouse interferon (100 IU/g), both. Survival animals, mass tumors,...
WISH cell cultures were irradiated 24 h after passage with 3 GHz microwaves for 30 min at intensites of 5 or 20 mW cm-2. After times from exposure 1, 4, 8, 12 and the cells incubated muCi ml-2 3H-glycine autoradiographs made using stripping film. The incorporation amino acid was measured four groups, 0-10, 10-20, 20-40 above 40 grains per cell. Karyometric analysis performed 12, 48 exposure. In an intensity cm-2, inhibition protein synthesis lowering nuclear volume enlargement nucleoli found...
50 newly prepared pyrimidine derivatives and trimethinium were tested for the inhibitory activity of vaccinia virus, Newcastle disease virus (NDV) western equine encephalomyelitis (WEE) multiplication using agar-diffusion plaque-inhibition test. Most exerted an effect on virus. The highest selective was found with 2-amino-5-dimethylaminomethyleneaminopyrimidine (derivative No. 35). Much lower observed several in WEE inhibition. Trimethinium not effective
The tandem cryo ion trap FRITZ allows the investigation of organometallic complexes as well transition metal cluster ions in gas phase with adsorbed reaction gases.The setup enables studies on uptake kinetics IR-PD action spectroscopy under conditions.In this talk we present dinitrogen to anions and cations regard elementary steps N2 activation.Supported by DFT modeling aim explain influence geometric electronic features activation process.