A5108633196- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Pain Management and Opioid Use
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Mechanisms and Treatments
- Airway Management and Intubation Techniques
- Botulinum Toxin and Related Neurological Disorders
- Hemodynamic Monitoring and Therapy
- Nausea and vomiting management
- Musculoskeletal pain and rehabilitation
- Pediatric Pain Management Techniques
- Nitric Oxide and Endothelin Effects
- Respiratory Support and Mechanisms
- Blood transfusion and management
- Pain Management and Treatment
- Tracheal and airway disorders
- Cardiac Ischemia and Reperfusion
- Opioid Use Disorder Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Anorectal Disease Treatments and Outcomes
- Anesthesia and Neurotoxicity Research
- Antibiotics Pharmacokinetics and Efficacy
- Hip and Femur Fractures
- Trauma, Hemostasis, Coagulopathy, Resuscitation
The University of Texas Medical Branch at Galveston
2008-2024
CU Shah Medical College and Hospital
2024
Memorial Hermann
2024
St Thomas' Hospital
2016-2023
Stanford University
2022
Heidelberg University
2017
Universidade de São Paulo
1997-2016
Universidade Estadual Paulista (Unesp)
2016
Thomas Jefferson University
2008
Moss Rehabilitation Hospital
2008
Use of opioids for chronic non-cancer pain (CNCP) has increased in recent years because this had been undertreated. There was also a simultaneous increase misuse and abuse opioids. Deaths due to such have risen as seen the many reports published every day local papers well medical literature. So, it is imperative that patients who are prescribed these medications be monitored adherence so can curtailed available those genuinely need them control. various screening tools monitor adherence,...
Background Reliable tests of correct anatomic placement the laryngeal mask airway (LMA) may enhance safety during use and minimize need for fiberoptic instrumentation manipulation through device. This study assessed correlation between outcomes nine clinical to place LMA position device as graded on a standard scale. Methods During 150 anesthetics, outcome was individually scored satisfactory (positive) or unsatisfactory (negative) LMA. Anatomic (by evaluation) by an anesthesiologist, who...
Reduced bioavailability of endothelium-derived nitric oxide associated with reperfusion could potentially exacerbate the inflammatory response during reperfusion. Evidence suggests pharmacologic effects inhaled may extend beyond pulmonary vasculature, and this is attributed to oxide-derived complexes in blood that ultimately orchestrate antiinflammatory effects. In study, authors evaluated potential for (80 ppm) attenuate inflammation instigated by ischemia-reperfusion a human model using...
BACKGROUND: Opioid prescribing in the United States is decreasing, however, opioid epidemic continuing at an uncontrollable rate. Available data show a significant number of deaths, primarily associated with illicit fentanyl use. It interesting to also note that no clear correlation between (either prescriptions or morphine milligram equivalent [MME] per capita), hospitalizations, and deaths. Furthermore, suggest 2016 guidelines from Centers for Disease Control Prevention (CDC) have resulted...
Tracheal stenosis, a narrowing of the trachea, often results from trauma, infections, or iatrogenic causes, leading to airway obstruction. This report discusses anaesthetic management 35-year-old male patient with recurrent tracheal stenosis undergoing tracheo-tracheal anastomosis. The had history road traffic accident, requiring multiple interventions including tracheostomy and laser excision for Jet ventilation was utilized during surgery optimal oxygenation. Effective preoperative...
Background: Opioids are effective for treating acute pain but have safety, tolerability, and addiction concerns while non-opioid analgesics limited efficacy. Suzetrigine, an oral, non-opioid, small molecule, selectively inhibits the voltage-gated sodium channel 1.8 (Na V 1.8) has potential to provide efficacious safe relief pain, without concerns. Methods: To evaluate suzetrigine treatment of we conducted two phase 3, randomized, double-blind, placebo- active-controlled trials in adults with...
BACKGROUND: Peripheral nerve stimulation (PNS) has been used for over 50 years to treat chronic pain by delivering electrical pulses through small electrodes placed near targeted peripheral nerves those outside the brain and spinal cord. Early PNS systems often required invasive neurosurgical procedures. However, since 2015, Food Drug Administration (FDA) approved percutaneously implanted leads neurostimulators offering a much less invasive, non-opioid option managing recalcitrant pain. The...
Objective We tested the hypothesis that pharmacologic properties of a small volume alphaalpha-cross-linked hemoglobin (alphaalphaHb) could effectively resuscitate pigs subjected to hemorrhage. Methods Fourteen hemorrhaged mean arterial pressure (MAP) 40 mm Hg for 60 minutes were treated with 4-mL/kg 2-minute infusion 10 g/dL alphaalphaHb or 7 human serum albumin, an oncotically matched control solution. Results The removal blood (17 +/- 1.5 mL/kg) caused typical physiologic responses...
Phantom limb pain can be challenging to treat. We present a patient who developed severe phantom after revision of her lower extremity amputation due the continued progression peripheral vascular disease. Multiple treatment modalities had been tried without success. Pulsed radiofrequency has successfully used manage number syndromes.The case report describes use pulsed for pain.The authors initially preformed regional blocks femoral and sciatic nerve with 0.375% bupivicaine 15 cc 50 microg...
Background General anesthesia in adult humans is associated with narrowing or complete closure of the pharyngeal airway. The purpose this study was to determine effect progressive mandibular advancement on airway size normal adults during intravenous infusion propofol for anesthesia. Methods Magnetic resonance imaging performed nine wakefulness and A commercially available intraoral appliance used manually advance mandible. Images were obtained without participants wearing under three...
Abstract Aim Imaging for pelvic floor defaecatory dysfunction includes defaecation proctography. Integrated total ultrasound (transvaginal, transperineal, endoanal) may be an alternative. This study assesses accuracy the detection of rectocele, intussusception, enterocele and dyssynergy compared with proctography, determines if can predict symptoms findings on Treatment is examined. Method Images 323 women who underwent integrated proctography between 2011 2014 were blindly reviewed. The...
The objective of this study was to identify cellular and plasma marker(s) post-I/R (ischaemia/reperfusion) in patients undergoing elective knee surgery where a tourniquet used facilitate bloodless surgical field. We evaluated the inflammatory redox response by measuring mRNA levels ICAM-1 (intercellular cell-adhesion molecule-1), MnSOD (manganese superoxide dismutase), GST-μ (glutathione transferase-μ) Cu/ZnSOD (copper/zinc dismutase) operated muscle blood cells pre-operatively...
In this study, we examined the utility of preoperative dobutamine stress echocardiograms (DSE) obtained for 85 patients in accordance with guidelines published by American College Cardiology (ACC) and Heart Association (AHA). The medical record each patient was reviewed to identify clinical criteria that indicated need a DSE, DSE results, therapeutic interventions rendered as result any perioperative cardiac morbidity. positive inducible ischemia 4 (4.7%), negative 74 (87.1%), nondiagnostic...
We sought to evaluate the efficacy, efficiency, and physiologic consequences of automated, endpoint-directed resuscitation systems compare them formula-based bolus resuscitation.
Anesthesiologists performing peripheral nerve blocks under ultrasound guidance look frequently back and forth between the patient screen during procedure. These head movements add time complexity to The head-mounted display (HMD) device is a commercially available video that connected machine projects image onto HMD glasses, enabling anesthesiologist monitor without ever needing away from patient. We hypothesized use of would decrease total procedure as well operator probe simulated...
The effects on gastric pH and volume of intravenous administration cimetidine metoclopramide before induction anesthesia were studied. Sixty ASA Class I patients scheduled for elective surgery randomly divided into four groups 15 each, the study was double-blinded. Group 1 received normal saline only; 11 4 mg/kg III 0.15 IV mglkg metoclopramide. All drugs given intravenously 30 min anesthesia. Gastric aspirates collected during anesthesia, 60 after drugs. Metoclopramide reduced significantly...
Oral tramadol, an atypical opioid approved in the United States (US) since 1995 and a Schedule IV controlled substance, has less abuse liability compared to II conventional opioids. Intravenous (IV) tramadol is not available US, but potential fill gap between non-opioid medications opioids for treatment of acute pain. This study evaluates management postoperative pain placebo standard-of-care active control. A phase 3, multicenter, double-blind, three-arm, randomized, placebo-...
OBJECTIVE: Pneumoperitoneum during laparoscopy results in transient oliguria and decreased glomerular filtration renal blood flow.The presence of elevated serum creatinine is suggestive acute injury.Serum cystatin C has been described as a new marker for the detection this type injury.In study, our aim was to compare rate estimated using levels with patients normal function who were undergoing laparoscopic surgery.METHODS: In total, 41 cholecystectomy or hiatoplasty recruited study.Blood...
Abstract Epidural steroid injections are used to treat lumbosacral radicular pain. However, there no Food and Drug Administration–approved corticosteroids for pain all currently available injectable carry safety warnings about their use in epidural injection procedures. SP-102 (dexamethasone viscous gel) was developed provide a safer option with extended local effect. In randomized, double-blind, placebo-controlled, multicenter trial, 401 patients moderate-to-severe leg from unilateral...
In this study, we examined the utility of preoperative dobutamine stress echocardiograms (DSE) obtained for 85 patients in accordance with guidelines published by American College Cardiology (ACC) and Heart Association (AHA). The medical record each patient was reviewed to identify clinical criteria that indicated need a DSE, DSE results, therapeutic interventions rendered as result any perioperative cardiac morbidity. positive inducible ischemia 4 (4.7%), negative 74 (87.1%), nondiagnostic...