A5015780301- Point processes and geometric inequalities
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects of Medicinal Plants
- Innovations in Concrete and Construction Materials
- Morphological variations and asymmetry
- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Plant Breeding
- Cholinesterase and Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Architecture and Computational Design
- Functional Brain Connectivity Studies
- Control and Dynamics of Mobile Robots
- BIM and Construction Integration
- Statistical Methods and Bayesian Inference
- Neurological disorders and treatments
- Neural dynamics and brain function
- Nicotinic Acetylcholine Receptors Study
- Robotic Path Planning Algorithms
- Structural Analysis and Optimization
- Dementia and Cognitive Impairment Research
- Trace Elements in Health
NextGen Aeronautics (United States)
2023
AeroVironment (United States)
2023
University of Glasgow
2022
Massachusetts Institute of Technology
1995-2021
Aarhus University Hospital
1993-2021
Aarhus University
2009-2018
Janssen (United States)
2016
University of Manitoba
1972-2015
Portland State University
2014
Agricultural Research Service - Plains Area
2010-2013
Abstract A stereological method for obtaining estimates of the total number neurons in five major subdivisions rat hippocampus is described. The new method, optical fractionator, combines two recent developments stereology: a three‐dimensional probe counting neuronal nuclei, disector, and systematic uniform sampling scheme, fractionator. disector results unbiased neuron number, i.e., that are free assumptions about size shape, unaffected by lost caps over‐projection, approach true an...
SummaryThe distinction between the neurodegenerative changes that accompany normal ageing and those characterise Alzheimer's disease is not clear. The resolution of this issue has important implications for design therapeutic investigative strategies. To end we have used modern stereological techniques to compare regional pattern neuronal cell loss in hippocampus related associated with disease.The was evaluated from estimates total number neurons each major hippocampal subdivisions 45...
Abstract The total numbers of neurons in five subdivisions human hippocampi were estimated using unbiased Stereological principles and systematic sampling techniques. method addresses the problems associated with results conclusions previous quantitative studies, virtually all which have been based on biased estimates neuron densities. For each subdivision, number was calculated as product estimate volume neuron‐containing layers numerical density layers. Each hippocampus cut into 3‐mm‐thick...
Recent evidence suggests that neural stem/precursor cells (NPCs) promote recovery in animal models with delayed neuronal death via a number of indirect bystander effects. A comprehensive knowledge how transplanted NPCs exert their therapeutic effects is still lacking. Here, we investigated the transplantation adult syngenic NPCs--injected intravenously 72 h after transient middle cerebral artery occlusion--on neurological recovery, histopathology and gene expression. NPC-transplanted mice...
Somatostatin-containing neurons of the striatum constitute fewer than 5% total neuronal population. Their involvement in feedforward inhibition spiny projection neurons, modulation other interneurons, and regulation regional blood flow indicates that this small population plays an important role processing information striatum. As a first step developing quantitative structural framework within which more rigorous analysis can be made functional circuitry striatum, we used modern unbiased...
Lineal structures in biological tissue support a wide variety of physiological functions, including membrane stabilization, vascular perfusion, and cell-to-cell communication. In 1953, Smith Guttman demonstrated stereological method to estimate the total length density (Lv) linear objects based on random intersections with two-dimensional sampling probe. Several methods have been developed ensure required isotropy object-probe intersections, isotropic-uniform-random (IUR) sections,...
The pathologic changes of Alzheimer disease (AD) evolve very gradually over decades before the becomes clinically manifest. Thus, it is not uncommon to find substantial numbers Aβ plaques and neurofibrillary tangles in autopsy brains older subjects with documented normal cognition, a state that we define as asymptomatic AD (ASYMAD). goal this study understand morphometric substrate ASYMAD compared mild cognitive impairment definite cases. We used designed-based stereology measure volumes...
Familial hyperkalemic hypertension (FHHt) is a monogenic disease resulting from mutations in genes encoding WNK kinases, the ubiquitin scaffold protein cullin 3 (CUL3), or substrate adaptor kelch-like (KLHL3). Disease-associated CUL3 abrogate kinase degradation cells, but it not clear how mutant forms of promote stability. Here, we demonstrated that an FHHt-causing (CUL3 Δ403–459) only retains ability to bind and ubiquitylate kinases KLHL3 also more heavily neddylated activated than WT CUL3....
Abstract The concept of casting concrete in fabrics, fabric formwork technology, has resurfaced at various times and different forms throughout the past century. following paper traces developments that have used fabrics for formwork, including types flexible controlled permeability pneumatic formwork. This presents a comprehensive historical overview listing key innovators, technological their advantages, offering examples structures built with these methods. information gathered is to...
Abstract Concrete is the most widely used construction material. Worldwide consumption of cement, strength‐giving component in concrete, now estimated to be 4.10 Gt per year, having risen from 2.22 just 10 years ago. This rate means that cement manufacture alone account for 5.2 % global carbon dioxide emissions. offers opportunity create structures with almost any geometry economically. Yet its unique fluidity seldom capitalized upon, concrete instead being cast rigid, flat moulds...
The mitochondrial Hsp60 chaperonin plays an important role in sustaining cellular viability. Its dysfunction is related to inherited forms of the human diseases spastic paraplegia and hypomyelinating leukodystrophy. However, it unknown whether requirement for neuron specific or a complete loss protein will impair mammalian development postnatal survival. In this study, we describe generation characterization mutant mouse line bearing inactivating gene-trap insertion Hspd1 gene encoding...