A5018856212- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Mast cells and histamine
- Psoriasis: Treatment and Pathogenesis
- Inflammatory Bowel Disease
- interferon and immune responses
The Francis Crick Institute
2018-2024
Abstract Intestinal immune responses to microbes are controlled by the cytokine IL-10 avoid pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq purified CD4 + T cells show that transcription factors Blimp-1 (encoded Prdm1 ) c-Maf co-dominantly regulate Il10 while negatively regulating proinflammatory cytokines in effector cells. Double-deficient fl/fl Maf Cd4 Cre mice infected Helicobacter hepaticus developed severe...
<ns4:p>Background CD4+ Th1 cells producing IFN-γ are required to eradicate intracellular pathogens, however if uncontrolled these can cause immunopathology. The cytokine IL-10 is produced by multiple immune including during infection and regulates the response minimise collateral host damage. In this study we aimed elucidate transcriptional network of genes controlling expression <ns4:italic>Il10</ns4:italic> proinflammatory cytokines, <ns4:italic>Ifng</ns4:italic> in differentiated from...
ABSTRACT Intestinal immune responses to commensals and pathogens are controlled by IL-10 avoid intestinal pathology. We show that the transcription factors Blimp-1 (Prdm-1) c-Maf co-dominant regulators of Il10 in Foxp3 + regulatory T cells, but also negatively regulate proinflammatory cytokines effector cells. Mice with cell-specific deletion Prdm-1, Maf or combination both did not develop inflammatory pathologies at steady state. Double deficient Prdm1 fl/fl Cd4 Cre mice infected...
<ns3:p><ns3:bold>Background: </ns3:bold>CD4<ns3:sup>+</ns3:sup> Th1 cells producing IFN-γ are required to eradicate intracellular pathogens, however if uncontrolled these can cause immunopathology. The cytokine IL-10 is produced by multiple immune including during infection and regulates the response minimise collateral host damage. In this study we aimed elucidate transcriptional network of genes controlling expression <ns3:italic>Il10 </ns3:italic>and proinflammatory cytokines,...