A5112967272- Cellular Mechanics and Interactions
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Advanced Fluorescence Microscopy Techniques
- Force Microscopy Techniques and Applications
University of California, Los Angeles
2023-2024
Abstract A new device termed “Optomagnetic Micromirror Arrays” (OMA) is demonstrated capable of mapping the stiffness distribution biomimetic materials across a 5.1 mm × 7.2 field view with cellular resolution. The OMA comprises an array 50 000 magnetic micromirrors optical grating structures embedded beneath elastic PDMS film, affixed on top. Illumination broadband white light beam onto these results in reflection microscale rainbow rays each micromirror. When applied, it causes micromirror...
Abstract We report a large field-of-view and high-speed videography platform for measuring the sub-cellular traction forces of more than 10,000 biological cells over 13mm 2 at 83 frames per second. Our Single-Pixel Optical Tracers (SPOT) tool uses 2-dimensional diffraction gratings embedded into soft substrate to convert cells’ mechanical stress optical colors detectable by video camera. The measures diverse cell types, including tightly connected tissue sheets near isolated cells. used this...