A5004890538- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Erythropoietin and Anemia Treatment
- Cancer Cells and Metastasis
- Wound Healing and Treatments
- Surgical Sutures and Adhesives
- Inhalation and Respiratory Drug Delivery
- Neutropenia and Cancer Infections
- Sarcoma Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Reproductive Biology and Fertility
- Trauma and Emergency Care Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neonatal Respiratory Health Research
- Chemotherapy-related skin toxicity
- Cardiac and Coronary Surgery Techniques
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Healthcare during COVID-19 Pandemic
- Nonmelanoma Skin Cancer Studies
- Facial Rejuvenation and Surgery Techniques
- Proteoglycans and glycosaminoglycans research
- Uterine Myomas and Treatments
- BRCA gene mutations in cancer
- Hemoglobinopathies and Related Disorders
Faculdade Evangélica do Paraná
2021-2024
University of Regensburg
1995-2015
Heinrich Heine University Düsseldorf
2009
Odense University Hospital
2009
University Hospital Regensburg
2006
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
1994
Ludwig-Maximilians-Universität München
1985-1987
München Klinik
1987
Max Planck Institute of Experimental Medicine
1969-1971
To analyze blood shed from the surgical field during oncologic surgery for tumor cells and to assess functional characteristics of these cells.Series 61 patients with cancer who underwent an abdominal, orthopedic, urological, gynecological, or head neck malignant tumor, blinded comparison 15 benign diseases undergoing surgery.A 500-bed center a tertiary care hospital.Tumor were isolated intraoperatively salvaged washed by density gradient centrifugation. They identified in cytospin specimens...
Intraoperative blood salvage is contraindicated in cancer surgery because of contaminating tumor cells and the risk systemic dissemination. On basis radiosensitivity cells, irradiation salvaged with 50 Gy proposed as a way to allow return blood.Elimination by was studied vitro from 10 cell lines 14 preparations after their addition red high numbers, or shed during surgery. Before gamma radiation, were isolated density gradient centrifugation tested for proliferative capacity colony assay....
The occurrence of soluble immune complexes (IC) in the cerebrospinal fluid (CSF) 14 multiple sclerosis (MS) patients, four acute polyradiculoneuritis 30 patients with other neurological diseases (OND) and disc prolapse (DP) was examined by a solid phase C1q-protein A binding assay (C1q-PABA) complement consumption test. IC-positive reactions were observed only C1q-PABA. indices determined C1q-PABA differed significantly (P < 0.01) when MS or OND patient groups compared to DP group. No...
Implementation of quality management in intraoperative blood salvage with controls product and process supports early recognition repair dysfunction if respective actions are laid down the handbook. In order to avoid insufficient improve quality, a broad understanding processes variables affecting is needed, which based on experimental tests. For this purpose use fresh whole as test protein parameter for determination plasma elimination rate favorable over outdated banked free hemoglobin....
Halothane has been shown to inhibit platelet aggregation and may, therefore, prevent intraoperative activation. The aim of this study was compare the effects volatile anaesthetics on activation, including transformation into an adhesive phenotype. After in vitro exposure anaesthetics, expression adhesion molecule P-selectin internalization receptor for von Willebrand factor (GPIb) were analysed by flow cytometry. In contrast desflurane or N2O, sevoflurane (≥0.5 MAC, P< 0.05), halothane (≥1.0...
A proposal of an expert group is reported that was put forward to facilitate the set-up a system for quality management in intra- and postoperative blood salvage. Retransfusion unwashed excluded since it cannot meet criteria modern transfusion medicine. Quality assurance necessary guarantee high autologous prepared during salvage with cell washing. It includes profound understanding composition shed preparation process, thorough documentation, measurement control parameters. Process can be...
The demand for intraoperative blood salvage (IBS) in cancer surgery originates from the high transfusion rate, unfavorable effects of anemia, and special impact risks such as immunomodulation tumor patients. advantages IBS are availability, low waste excellent quality autologous, unstored blood. Effective elimination cell dissemination by retransfusion wound can be achieved only irradiation. Combining established methods irradiation is feasible allows efficient saving For Jehovah's witnesses...
Autologe Transfusion wurde eingesetzt, um den hohen Blutbedarf bei Skolioseoperationen zu senken. Die Einsparung etwa der Hälfte des Blutverlustes durch intraoperative Autotransfusion (35 Patienten) führte einer entsprechenden Reduktion an homologer Transfusion. Erst die Kombination von präoperativer Eigenblutspende und intraoperativer (37 konnte Fremdblutgabe vielen Patienten völlig vermieden werden. Tiefgefrierung machte Blutspende unabhängig Lagerungsdauer ermöglichte es, auch...
Introdução: Câncer é o nome designado às neoplasias malignas que acometem órgãos ou tecidos, sendo basicamente doença genômica. As modificações genéticas podem acontecer em células somáticas hereditárias. Quando diagnosticado dano gênico específico, pode ser necessário aconselhamento genético, de acordo com critérios seleção. Objetivo: Traçar perfil epidemiológico pacientes oncológicos, focando nas anormalidades identificadas e avaliar a efetividade genético. Método: Coleta dados dos...
Introdução: Sarcomas do estroma endometrial são raros, originando-se no tecido de sustentação das glândulas endometriais. Classificam-se em baixo grau (SEEBG), alto e indiferenciado. Os SEEBGs, agressivos, costumam apresentar sintomas, como sangramento uterino anormal, dor pélvica dismenorreia. Relato caso: Mulher 44 anos, inicialmente diagnosticada com leiomioma epitelioide; dois anos mais tarde, avaliação histopatológica, o mioma pariu, sugerindo SEEBG. Histerectomia total confirmou...
Schlüsselwörter: cancer surgery - intraoperative blood salvage disseminated tumor cells irradiation
Because of a still growing demand for blood which is contrasted by decreasing number donations and because multiple transfusion risks, it necessary to consider intraoperative salvage also in cancer surgery. In this context irradiation essential the elimination contaminating tumor cells. As demonstrated usage, combination two established techniques feasible approach procedure. With respect increasing costs banked highly cost-effective. The efficacy saving evident while its impact on outcome...