A5101648166- Cancer, Lipids, and Metabolism
- Water Quality Monitoring Technologies
- Skin and Cellular Biology Research
- Underwater Vehicles and Communication Systems
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory mediators and NSAID effects
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Oral Health Pathology and Treatment
- Cancer-related molecular mechanisms research
Zhengzhou University
2023-2024
Henan Provincial People's Hospital
2023-2024
Henan University
2023
Long non-coding RNAs (lncRNAs) have been revealed to harbor open reading frames (ORFs) that can be translated into small peptides. The peptides may participate in the pathogenesis of colorectal cancer (CRC). Herein, we investigated role a lncRNA BVES-AS1-encoded peptide tumorigenesis. Through bioinformatic analysis, BVES-AS1 was predicted encoding potential and associated with poor prognosis patients CRC. In CRC cells, validated encode 50-aa-length micro-peptide, named BVES-AS1-201-50aa,...
Abstract Colorectal cancer (CRC) arises via the progressive accumulation of dysregulation in key genes including oncogenes and tumor-suppressor genes. Prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2) acts as an oncogenic driver CRC. Here, we explored upstream transcription factors (TFs) responsible for elevating PTGS2 expression CRC cells. The results showed that silencing repressed cell growth, migration invasion HCT116 SW480 two fragments (499–981 bp) (1053–1434 were...