A5032957677- Microwave-Assisted Synthesis and Applications
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Quantum Dots Synthesis And Properties
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 and healthcare impacts
- Advanced Nanomaterials in Catalysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Glycosylation and Glycoproteins Research
- Reproductive Health and Contraception
- Medical Imaging Techniques and Applications
- Chemical Synthesis and Analysis
- Fungal Plant Pathogen Control
- Nanocluster Synthesis and Applications
- Peptidase Inhibition and Analysis
- Gynecological conditions and treatments
- Synthesis and Reactions of Organic Compounds
- Graphene and Nanomaterials Applications
Trinity Health
2024
Mercy Hospital
2019-2021
Mercy Medical Center
2019-2021
St. Mary Mercy Livonia
2019-2021
Trinity Health Ann Arbor Hospital
2021
Cooper Green Mercy Hospital
2020
Beth Israel Deaconess Medical Center
2006-2009
Hadassah Medical Center
2009
Massachusetts Institute of Technology
2009
Rice University
2008
A significant portion of the field nanomedicine is predicated on being able to target nanoparticles sites disease. However, in vivo biodistribution and clearance are poorly understood. In this study, a novel formulation near-infrared fluorescent InAs(ZnS) quantum dots was synthesized coated with systematically increasing chain length PEG. We found that varying PEG resulted major changes organ/tissue-selective from body.
TM601 is a synthetic form of chlorotoxin, 36-amino acid peptide derived from the venom Israeli scorpion, Leirius quinquestriatus, initially found to specifically bind and inhibit migration glioma cells in culture. Subsequent studies demonstrated specific vitro binding additional tumor cell lines. Recently, we that proliferating human vascular endothelial are only normal line tested exhibits TM601. Here, identify annexin A2 as novel partner for multiple lines umbilical vein (HUVEC). We...
Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation SPECT the "gold standard" tomography breast cancer microcalcifications can now be compared optimized.
A new class of water-soluble C60 transfecting agents has been prepared using Hirsch−Bingel chemistry and assessed for their ability to act as gene-delivery vectors in vitro. In an effort elucidate the relationship between hydrophobicity fullerene core, hydrophilicity water-solubilizing groups, overall charge state gene delivery expression, several different derivatives were synthesized yield either positively charged, negatively or neutral chemical functionalities under physiological...
The chemokine stromal-derived factor-1alpha (SDF-1alpha, CXCL12) and its receptor CXCR4 are implicated as key mediators of hematopoietic stem cell retention, cancer metastasis, HIV infection. Their role in myocardial infarction (MI) is not well defined. noninvasive vivo quantitation expression central to understanding importance these diverse processes the cardiac response injury.Recombinant SDF-1alpha was radiolabeled under aprotic conditions purified by gel-filtration chromatography (GFC)...
Adamantane scaffolds for affinity maturation of prostate cancer specific ligands low molecular mass are described. These modular and can be used conjugation up to three an additional effector molecule by standard peptide coupling techniques. The potential the is demonstrated with multimerization GPI 1, a small molecule. A detailed study multimerized conjugates near-infrared fluorophores their binding properties different cell lines shows these types positive membrane antigen (PSMA). We...
Small-molecule ligands specific for prostate-specific membrane antigen (PSMA) have the potential to improve prostate cancer imaging. However, highly charged are difficult label with 99mTc and purify. In this study, we present an adamantane-trimerized small molecule that has nanomolar binding PSMA also 12 negative charges.To convert into a clinically viable SPECT diagnostic, developed simple, cartridge-based, solid-phase prelabeling strategy that, within 25 min, converts readily available...
Abstract The synthesis of heterocyclic compounds containing pyrimidine, pyrazoline, isoxazoline and cyclohexenone ring from chalcone derivatives anisole 3′4′-methylenedioxy phenyl under 'dry conditions' using microwaves by conventional methods are described.
Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to quinolone nucleus increase antimicrobial activity and improve pharmacokinetic performance. A major advance occurred during 1980's with that a fluorine at position-6 conferred broad potent activity, (e.g. norfloxacin) but still relatively less for Gram-positive antiaerobic organisms than Gram-negative bacteria. Subsequent developments produced quinolones further improvements, predominantly...
Abstract A novel synthetic method for the synthesis of 1,2,4-triazoles have been described starting from 1,3,4-thiadiazoles by adsorbing on acidic alumina under microwave irradiations (MWI). Key Words: Microwave IrradiationSolid SupportTriazolesThiadiazolesOxadiazoles
Abstract The production of disease‐targeted agents requires the covalent conjugation a targeting molecule with contrast agent or therapeutic, followed by purification product to homogeneity. Typical molecules, such as small molecules and peptides, often have high charge‐to‐mass ratios and/or hydrophobicity. Contrast therapeutics themselves are also diverse, include lanthanide chelates for MRI, 99m Tc SPECT, 90 Y radiotherapy, 18 F derivatives PET, heptamethine indocyanines near‐infrared...
An expeditious solvent-free synthesis of pyrazolino/iminopyrimidino/thioxopyrimidino imidazoline derivatives from readily accessible oxazolones on solid support using microwaves is described. The reaction time has been brought down hours to minutes with improved yield as compared conventional heating.