Louise Rosias
A5093583477- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Treatment and Research
- PARP inhibition in cancer therapy
- Advanced Breast Cancer Therapies
- Cutaneous Melanoma Detection and Management
- Glioma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
KU Leuven
2023
Abstract Inflammatory breast cancer (IBC) is a rare (1%–5%), aggressive form of cancer, accounting for approximately 10% mortality. In the localized setting, standard care neoadjuvant chemotherapy (NACT) ± anti-HER2 therapy, followed by surgery. Here we investigated associations between clinicopathologic variables, stromal tumor-infiltrating lymphocytes (sTIL), and pathologic complete response (pCR), prognostic value pCR. We included 494 patients with IBC treated NACT from October 1996 to...
<p>Association of RCB with clinicopathologic features and treatment in all patients. <b>A–C,</b> Forest plots showing the association RCB, either as class or continuous score, standard variables (A), sTILs (continuous %; B), (categorical; C) evaluated by regression analyses Analyses were performed on subset patients diagnosed treated at UZ Leuven, Belgium.</p>
<p>sTIL scoring and its association with clinicopathological features in all patients. <b>A,</b> Distribution of sTIL (continuous) the entire cohort subtypes. <b>B,</b> (category) <b>C,</b> Forest plots showing (categorical) standard clinicopathologic variables evaluated by regression analyses patients.</p>
<p>sTIL scoring and its association with clinicopathological features in all patients. <b>A,</b> Distribution of sTIL (continuous) the entire cohort subtypes. <b>B,</b> (category) <b>C,</b> Forest plots showing (categorical) standard clinicopathologic variables evaluated by regression analyses patients.</p>
<div>Abstract<p>Inflammatory breast cancer (IBC) is a rare (1%–5%), aggressive form of cancer, accounting for approximately 10% mortality. In the localized setting, standard care neoadjuvant chemotherapy (NACT) ± anti-HER2 therapy, followed by surgery. Here we investigated associations between clinicopathologic variables, stromal tumor-infiltrating lymphocytes (sTIL), and pathologic complete response (pCR), prognostic value pCR. We included 494 patients with IBC treated NACT from...
<p>Supplementary Figure 1 shows examples of sTIL scoring in skin on H&E images.</p>
<p>Association of pCR with OS. <b>A,</b> Kaplan–Meier curves OS according to pCR. <b>B,</b> Forest plots showing the association and standard clinicopathologic treatment variables quantified by Cox regression.</p>
<p>Association of pCR with clinicopathologic features and treatment in all patients. <b>A–C,</b> Forest plots showing the association standard variables (A), sTILs (continuous %; B), (categorical; C) evaluated by regression analyses patients.</p>
<p>Association of pCR with clinicopathologic features and treatment in all patients. <b>A–C,</b> Forest plots showing the association standard variables (A), sTILs (continuous %; B), (categorical; C) evaluated by regression analyses patients.</p>
<p>Supplementary Figure 12 shows analyses of the association RCB with DRFS.</p>
<p>Supplementary Figure 2 shows an overview of data flow in the study.</p>
<p>Supplementary Figure 13 shows analyses of the association sTIL with DFS and OS.</p>
<p>Supplementary Figure 11 shows analyses of the association RCB with DRF and OS.</p>
<p>Association of pCR with OS. <b>A,</b> Kaplan–Meier curves OS according to pCR. <b>B,</b> Forest plots showing the association and standard clinicopathologic treatment variables quantified by Cox regression.</p>
<p>Supplementary Figure 12 shows analyses of the association RCB with DRFS.</p>
<p>Supplementary Figure 13 shows analyses of the association sTIL with DFS and OS.</p>
<p>Supplementary Figure 11 shows analyses of the association RCB with DRF and OS.</p>
<p>Supplementary Figure 3 shows concordance of sTIL scoring between tumor and skin biopsies.</p>
<p>Baseline clinical and pathologic characteristics of patients in the entire cohort each breast cancer subgroups</p>
<p>Supplementary Figure 1 shows examples of sTIL scoring in skin on H&E images.</p>
<p>Association of pCR with DFS. <b>A,</b> Kaplan–Meier curves DFS according to pCR. <b>B,</b> Forest plots showing the association and standard clinicopathologic treatment variables quantified by Cox regression.</p>
<p>Supplementary Figure 14 shows analyses of the association sTIL with DRFS.</p>
<p>Supplementary Figure 14 shows analyses of the association sTIL with DRFS.</p>
<p>Supplementary Figure 2 shows an overview of data flow in the study.</p>
<p>Supplementary Figure 10 shows analyses of the association pCR with DRFS.</p>