A5101741723- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and biological activity of medicinal plants
- High Altitude and Hypoxia
- Health, Environment, Cognitive Aging
- Advanced Chemical Sensor Technologies
- Chromatography in Natural Products
- Adipose Tissue and Metabolism
- Ginseng Biological Effects and Applications
Dalian Medical University
2024-2025
First Affiliated Hospital of Dalian Medical University
2024-2025
Qing-Yi Recipe, a classic traditional Chinese medicine (TCM), is widely used for treating acute diseases of the abdomen, especially pancreatitis, efficacy which has been demonstrated in more than thirty clinical trials. However, in-vivo pharmacodynamic material basis this formula remains unclear. A sensitive and accurate method quantifying twenty-two potential bioactive constituents Recipe biological samples was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), fully...
The profiling of metabolites provides an immediate snapshot that depicts crucial physiological information, holding immense potential for the early diagnosis and prognosis diseases, including diabetes. Herein, we proposed optimized in-depth target-based metabolome platform through integration six distinct conditions, a normal phase, pre-column chemical derivatization four reversed phase separation methods quantification total 1609 small molecules (32 sub-classes) in serum after normalization...
This study investigates the metabolic changes induced by endurance exercise, specifically race walking, in a cohort of 19 athletes. Blood samples were collected at four time points: pre-exercise (REST), immediately post-exercise (STAT), 3 hours into recovery (REC3), and 22 (REC22). A total 859 metabolites identified through untargeted method, 465 411 lipids targeted methods. Rigorous quality control measures implemented throughout to ensure data reliability. The comprehensive dataset, which...