A5101509617- DNA Repair Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Vietnamese History and Culture Studies
- Microtubule and mitosis dynamics
- Enzyme Catalysis and Immobilization
- Japanese History and Culture
- Cancer-related Molecular Pathways
- Microbial metabolism and enzyme function
- CRISPR and Genetic Engineering
- Amino Acid Enzymes and Metabolism
- Military History and Strategy
- Carcinogens and Genotoxicity Assessment
- Vector-Borne Animal Diseases
- Hand Gesture Recognition Systems
- Genomics and Chromatin Dynamics
- Algal biology and biofuel production
- Immunodeficiency and Autoimmune Disorders
- Antioxidant Activity and Oxidative Stress
- vaccines and immunoinformatics approaches
- State Capitalism and Financial Governance
- Global Political and Social Dynamics
- Bacterial Genetics and Biotechnology
- Data Stream Mining Techniques
- Carbohydrate Chemistry and Synthesis
- Comics and Graphic Narratives
Lead City University
2020
Health Education England
2019
Genomics (United Kingdom)
2019
Wilmington University
2001-2016
DuPont (United States)
2001-2016
Experimental Station
2001-2016
University of Birmingham
2007-2015
Naval Medical Research Command
2013
Walter Reed National Military Medical Center
2013
Cancer Research UK
2007-2009
The MRE11–RAD50–Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in microscopically discernible nuclear foci. Focus formation by the MRN is dependent on MDC1, a large protein that directly interacts with phosphorylated H2AX. In this study, we identified region MDC1 essential for focal accumulation damage. This contains multiple conserved acidic sequence motifs are constitutively vivo. We show these efficiently caseine kinase 2 (CK2)...
Cellular DNA double-strand break-repair pathways have evolved to protect the integrity of genome from a continual barrage potentially detrimental insults. Inherited mutations in genes that control this process result an inability properly repair damage, ultimately leading developmental defects and also cancer predisposition. Here, we describe patient with previously undescribed syndrome, which termed RIDDLE syndrome (radiosensitivity, immunodeficiency, dysmorphic features learning...
The omega-3 fatty acid, cis-5,8,11,14,17-eicosapentaenoic acid (C20:5; EPA) has wide-ranging benefits in improving heart health, immune function, and mental health. A sustainable source of EPA production through fermentation metabolically engineered Yarrowia lipolytica been developed. In this paper, key fed-batch conditions were identified to achieve 25% the yeast biomass, which is so far highest titer reported literature. Dynamic models process established for analyzing, optimizing, scaling...
Medical Service of Grady Hospital and the Department Medicine, Emory University School Atlanta, Georgia
A study of the component in serum and tissue extracts responsible for non-specific inhibition hemagglutination with mumps virus PR8 Lee strains influenza has yielded following results: 1. The inhibitory factor was found high titer human saline various organs procured at autopsy (lung, liver,kidney, spleen). titers these were usually higher than titers, whereas muscle invariably lower. 2. Similar results obtained from normal rabbits guinea pigs. 3. not affected by heating to 75 degrees C. 30...
UNDULANT fever occurs frequently among laboratory workers handling cultures of Brucella organisms.1 This report is a summary such infections in 17 persons engaged investigative work with these organisms. The organization the laboratories at Camp Detrick made it possible to gather serologic data before infection. These cases offered an unusual opportunity observe clinical course this disease from onset illness and submit several chemotherapeutic agents trial.A vaccine was given all members...
Human mediator of DNA damage checkpoint 1 (hMDC1) is an essential component the cellular response to double strand breaks. Recently, hMDC1 has been shown associate with a subunit anaphase-promoting complex/cyclosome (APC/C) (Coster, G., Hayouka, Z., Argaman, L., Strauss, C., Friedler, A., Brandeis, M., and Goldberg, M. (2007) J. Biol. Chem. 282, 32053-32064), key regulator mitosis, suggesting possible role for in controlling normal cell cycle progression. Here, we extend this work show that...
Background: In a prior study, DNA prime / adenovirus boost vaccine (DNA/Ad) expressing P. falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1) (NMRC-M3V-D/Ad-PfCA Vaccine) induced 27% protection against controlled human malaria infection (CHMI). To investigate the contribution of priming, we tested efficacy alone (NMRC-M3V-Ad-PfCA ) in Phase 1 clinical trial.Methodology/Principal Findings: The regimen was single intramuscular injection with two non-replicating...
Journal Article War Plan Orange: The U.S. Strategy to Defeat Japan, 1897–1945. By Edward S. Miller. (Annapolis: Naval Institute Press, 1991. xxiv + 509 pp. $34.95, ISBN 0-87021-759-3.) Get access Jonathan G. Utley University of Tennessee, Knoxville Search for other works by this author on: Oxford Academic Google Scholar American History, Volume 79, Issue 2, September 1992, Pages 688–689, https://doi.org/10.2307/2080131 Published: 01 1992
Epidemiological Study of Lymphogranuloma Venereum, Employing the Complement-Fixation Test Paul B. Beeson, and Edward S. Miller CopyRight https://doi.org/10.2105/AJPH.34.10.1076 Published Online: August 29, 2011
Exhaust gas recirculation (EGR) is currently widely used in commercial diesel engines to provide an effective solution reducing the levels of nitrogen oxide (NOX) emissions. However, this comes at expense exponential increase particulate matter (PM) emissions resulting directly from dilution effect (i.e. reduction oxygen availability), as well a further penalty arising exhaust such soot and hydrocarbons. In our earlier work it was observed that filtered EGR (FEGR) able play significant role...
Summary Streptomycin, penicillin and sodium sulfadiazine were tested for efficacy in experimental anthrax infections mice. Maximal survival rates of 92 per cent obtained with streptomycin, 58 penicillin, only 5 sulfadiazine. Latent not present treated animals surviving 28 days after inoculation lethal doses B. anthracis spores.
Abstract A microbial oxidation process for the production of p ‐hydroxybenzoate (HBA) from toluene is reported. The reaction was studied in fed‐batch fermentations using a recombinant Pseudomonas putida grown on glutamate as sole carbon and energy source with salicylate IPTG induction tmoABCDE , pchCF phbz pathway genes, respectively. An average volumetric HBA productivity 13.4 mg L −1 h obtained under rapid growth conditions (glutamate excess), giving an titer 132 after 9.8 fermentation....
To support the delivery of UK's 100,000 Genomes Project, Health Education England's Genomics Programme developed a suite resources, including 3-week Massive Open Online Course (MOOC) on whole genome sequencing via FutureLearn platform. This MOOC is synchronous learning event, with course educators and mentors (NHS healthcare science trainees in genomics) facilitating experience real time. Crucially, platform allows participants to interact learn from each other's experiences. The evaluation...