A5064057435- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Thyroid Cancer Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- S100 Proteins and Annexins
- Neuroendocrine Tumor Research Advances
- Medical Imaging Techniques and Applications
- Metal and Thin Film Mechanics
- Protease and Inhibitor Mechanisms
Johannes Gutenberg University Mainz
2022-2025
All India Institute of Medical Sciences
2023
Radiopharmaceuticals based on the highly potent FAP inhibitor (FAPi) UAMC-1110 have shown great potential in molecular imaging, but short tumor retention time of monomers do not match physical half-lives important therapeutic radionuclides 177Lu and 225Ac. This was improved with dimer DOTAGA.(SA.FAPi)2, pharmacological radiolabeling properties still need optimization. Therefore, novel FAPi homodimers DO3A.Glu.(FAPi)2 DOTAGA.Glu.(FAPi)2. were synthesized quantitatively radiolabeled 68Ga, 90Y,...
Aim: The study aimed to analyze the long-term outcomes of [177Lu]Lu-DOTAGA.FAPi dimer therapy in individuals diagnosed with radioiodine-resistant (RAI-R) follicular cell-derived thyroid cancer. Materials and Methods: In this retrospective study, 73 patients RAI-R carcinoma who had undergone multiple lines previous treatments were included. Following [68Ga]Ga-DOTA.SA.FAPi positron emission tomography-computed tomography scan, among patients, 65 received monotherapy a median activity 5.5 GBq...
Purpose This study aimed to compare the diagnostic efficacy of [ 68 Ga]Ga-DOTA.SA.FAPi and 18 F]F-FDG PET/CT for detecting primary metastatic lesions in sarcoma patients. Materials Methods The analysis included both patient-based lesion-based comparisons scans individuals with histologically confirmed sarcoma. Results A total 23 patients (mean age 43.0 ± 16.5 years; range: 21–76 years) underwent scans. Histological distribution 30% synovial sarcoma, 13% liposarcoma, 21.7% leiomyosarcoma, 70%...
Background: A theranostic probe for accurate staging and treatment is crucial the management of medullary thyroid cancers (MTCs). The abundance stroma in most cancers, including MTC, opens new avenues selecting cancer-associated fibroblasts (CAFs) as molecular imaging therapeutic targets. [68Ga]Ga-labeled fibroblast activation protein inhibitor (FAPi) molecules have gained importance alternative agents cancers. purpose this study was to compare detection efficiency primary metastatic lesions...
This study aimed to compare the diagnostic performance of [68Ga]Ga-DOTA.SA.FAPi with that [18F]F-FDG PET/CT in detecting primary and metastatic lesions breast cancer. scans histologically proven cancer patients were compared according patient-based lesion-based analysis. Forty-seven a mean age 44.8 ± 9.9 years (range: 31-66 years) evaluated. A total 85% had invasive ductal carcinoma, 15% lobular carcinoma. The tracer uptake [SULpeak, SULavg, median tumor-to-background ratio (TBR)] was...
Abstract Purpose This study explores the use of fibroblast activation protein inhibitors (FAPI) targeting radiopharmaceuticals as a new approach for pan-cancer treatment, focusing on key factors affecting their effectiveness. We hypothesized that adjusting administered radiotracer dose one could enhance tumor-to-background ratios. Methods In dose-escalation with PC3 xenografts, all radiotracers were at doses between 10 and 1500 pmol, followed by biodistribution PET/CT imaging. Their...
Abstract This review describes the basic principles of radiometal-theranostics and its dawn based on development positron-emitting 86 Y Y-labeled radiopharmaceuticals to quantify biodistribution dosimetry 90 analogue therapeutics. The nuclear inorganic (including cross section data, irradiation, radiochemical separation recovery) led preclinical clinical evaluation citrate EDTMP complexes yielded organ radiation doses in terms mGy/MBq Y. approach was extended [ 86/90 Y]Y-DOTA-TOC, yielding...
Abstract Purpose [ 18 F]F-FDG is a standard and valuable diagnostic imaging modality for radioiodine-resistant follicular-cell derived thyroid cancers (RAI-R FCTC). Recently, molecular probes targeting cancer-associated fibroblasts (CAFs) have gained prominence proved to be potential alternative PET/CT in oncological imaging. This study aimed compare the efficacy of 68 Ga]Ga-DOTA.SA.FAPi F]-FDG RAI-R FCTC patients. Methods The retrospective included 117 patients [68 females, 49 males; mean...