A5063219083- Epilepsy research and treatment
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Neuroscience and Neuropharmacology Research
- Artificial Intelligence in Healthcare and Education
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Central Venous Catheters and Hemodialysis
- Clinical Reasoning and Diagnostic Skills
- Vascular anomalies and interventions
- Adipose Tissue and Metabolism
- Intestinal Malrotation and Obstruction Disorders
- Cardiac Imaging and Diagnostics
- Neural dynamics and brain function
- Autoimmune and Inflammatory Disorders Research
- Esophageal and GI Pathology
- Fungal Infections and Studies
- Lysosomal Storage Disorders Research
- Adrenal Hormones and Disorders
- Abdominal vascular conditions and treatments
- Psychosomatic Disorders and Their Treatments
- Autophagy in Disease and Therapy
- Cellular transport and secretion
University of California, Davis
2024-2025
University of California Davis Medical Center
2024
University of Pennsylvania
2014-2022
Emory University
2022
King's College London
2020
University of North Carolina at Chapel Hill
2010
Background For patients with drug-resistant focal epilepsy, surgical resection of the epileptogenic zone (EZ) is an effective treatment to control seizures. Accurate localization EZ crucial and typically achieved through comprehensive presurgical approaches such as seizure semiology interpretation, electroencephalography (EEG), magnetic resonance imaging (MRI), intracranial EEG (iEEG). However, interpreting challenging because it heavily relies on expert knowledge. The semiologies are often...
Status epilepticus (SE) is a neurologic emergency that requires urgent recognition and medical management. SE management remains heterogeneous across centers. We analyzed treatment protocols from level 3 4 epilepsy Discrete data including stabilization measures, timing of phases, medications, doses, routes administration were collected each protocol described using frequency for categorical variables median continuous variables. The distribution times dosing compared with the AES guideline....
Abstract Objective To predict one‐year seizure freedom, using a combination of relevant clinical variables, following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in series 101 patients. Methods Eight predictors freedom were selected based on their association with medial epilepsy: (1) MRI evidence sclerosis (MTS); (2) unitemporal interictal epileptiform discharges; (3) absence generalized tonic–clonic seizures; (4) history febrile (5) onset ≤16 years; (6) an...
Abstract Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome B) is an autosomal recessive lysosomal storage disorder caused by the deficiency of alpha- N -acetylglucosaminidase activity, leading to increased levels nondegraded heparan sulfate (HS). A mouse model has been useful evaluate novel treatments for MPS IIIB, but limitations. In this study, we evaluated naturally occurring canine onset and progression biochemical neuropathological changes during preclinical stages (onset...
Adrenal venous sampling (AVS) is the definitive evaluation for primary aldosteronism (PA). Pre-AVS cross-sectional imaging does not reduce need AVS. The goal of this study was to examine whether performing AVS prior could decrease use in PA at a high volume, experienced center.We performed retrospective analysis all procedures (n = 337) done from 2001-2013. Patients whose reports were unavailable 90) or non-diagnostic 12) excluded. using modified Mayo technique. Univariate utilized χ² test...
Abstract Background For patients with drug-resistant focal epilepsy (DRE), surgical resection of the epileptogenic zone (EZ) is an effective treatment to control seizures. Accurate localization EZ crucial and typically achieved through comprehensive presurgical approaches such as seizure semiology interpretation, electroencephalography (EEG), magnetic resonance imaging (MRI), intracranial EEG (iEEG). However, interpreting poses challenges because it relies heavily on expert knowledge often...
The approval of the interleukin (IL)-17A inhibitor secukinumab (Cosentyx; Novartis International, King Prussia, PA) was a major advance in psoriasis treatment, with most patients experiencing 75% reduction severity.1 Known side effects include an increase minor infections, but no infectious adverse events and nervous system involvement,1-4 leading to broad use clinical trials targeting IL-17 pathway. Here, we describe patient administered who presented severe neurologic deficits due...