A5010991040- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Genetic Neurodegenerative Diseases
- Conducting polymers and applications
- Cardiovascular Syncope and Autonomic Disorders
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Restless Legs Syndrome Research
- Nuclear Receptors and Signaling
University of Brescia
2020-2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2021-2025
Biosensor (Italy)
2023-2024
Surgical Specialties (United States)
2021
Mechanisms underlying the role of diabetes mellitus (DM) as modulator severity in Parkinson's Disease (PD) remain unclear. Aim this study was to investigate impact DM on nigrostriatal dopaminergic vulnerability considering two independent cohorts drug-naive PD patients (PPMI and DNA studies). Patients with without were first compared then matched for age, sex, symptoms severity. Differences 123I-FP-CIT binding molecular connectivity alterations tested within pathway. 269 enrolled (PPMI,...
Background: There is a need for simplified classification systems capable of effectively stratifying Parkinson's disease (PD) in routine clinical practice. Objectives: Identification PD subtypes integrating neuroimaging and features, widely used to support diagnosis. Methods: We included, from Progression Markers Initiative (PPMI), 249 de novo early diagnosed patients. Two step clustering analysis was run on 123I-FP-CIT-SPECT striatal uptake [D+/D] motor impairment [M+/M]. The emerging...
To evaluate whether orthostatic hypotension (OH) or supine hypertension (SH) is associated with brain atrophy and white matter hyperintensities (WMH), we analyzed clinical radiologic data from a large multicenter consortium of patients Parkinson disease (PD) dementia Lewy bodies (DLB).Supine blood pressure (BP) structural MRI were extracted PD DLB evaluated at 8 tertiary-referral centers in the United States, Canada, Italy, Japan. OH was defined as systolic/diastolic BP fall ≥20/10 mm Hg...
Dementia with Lewy bodies (DLB) is typically characterized by parietal, temporal, and occipital atrophy, but less known about the newly defined prodromal phases. The objective of this study was to evaluate structural brain alterations in DLB (p-DLB) as compared healthy controls (HC) full-blown dementia (DLB-DEM).The included 42 patients (n = 20 p-DLB; n 22 DLB-DEM) 27 HC a standardized neurological assessment 3-tesla magnetic resonance imaging. Voxel-wise analyses on gray-matter cortical...
Brain hypometabolism patterns have been previously associated with cognitive decline in Parkinson's disease (PD). Our aim is to evaluate the impact of single-subject fluorodeoxyglucose (FDG)-PET brain on long-term and motor outcomes PD.Forty-nine non-demented PD patients baseline FDG-PET data underwent an extensive clinical follow-up for 8 years. The ability predict progression was evaluated using Cox regression mixed ANCOVA models.Participants were classified according pattern typical (n =...
Abstract Methods This study assessed data from two cohorts of patients with alpha‐synucleinopathies (University Brescia and University Rome Tor‐Vergata cohorts). Consecutive participants video‐polysomnography‐confirmed iRBD, Parkinson's disease (PD), dementia Lewy bodies (DLB) controls underwent neurological, clinical 123 I‐FP‐CIT SPECT imaging assessments. Individuals iRBD were longitudinally monitored to collect phenoconversion PD or DLB. The main outcome was identify whole brain measures...
Abstract Background CSF and plasma neurofilament light chain (NfL) levels have been consistently proposed as reliable markers of neurodegeneration able to discriminate between Parkinson’s disease (PD) atypical parkinsonisms. Increased Serum NfL might predict worse motor cognitive progression in PD patients at single subject level. Method was assessed a longitudinal study including 93 with 27 DLB who underwent an extensive assessment after 2 years follow‐up. The evaluated the correlation...