A5022003895- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Neonatal Respiratory Health Research
- Genomics and Chromatin Dynamics
- Anesthesia and Neurotoxicity Research
- RNA modifications and cancer
- Pancreatic function and diabetes
- Amino Acid Enzymes and Metabolism
Inserm
2023-2024
Sorbonne Université
2023-2024
Institut de Biologie Paris-Seine
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Universitat de Barcelona
2024
The saltatory migration of neurons is essential for brain formation. Whether mechanical stimuli regulate this process unknown. Here we show that the primary cilium acts as a sensor through GPR161. Using an ex vivo neuronal model and microfluidic assays, demonstrate fluid shear stress induces via mechanoreceptor GPR161 at cilium, with its mechanosensitive Helix 8 being essential. We activates recently discovered cAMP/PKA signaling pathway leading to phosphorylation NDE1, dynein complex...
The fragile X syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is first monogenic cause autism spectrum disorder. FXS results from absence RNA-binding protein FMRP (fragile messenger ribonucleoprotein). Neuronal migration an essential step brain development allowing displacement neurons their germinal niches to final integration site. precise role in neuronal remains largely unexplored. Using live imaging postnatal rostral migratory stream (RMS) Fmr1...
The Fragile X Syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is first monogenic cause Autism Spectrum Disorder. FXS results from absence RNA-binding protein FMRP (Fragile Messenger Ribonucleoprotein).Neuronal migration an essential step brain development allowing displacement neurons their germinal niches to final integration site. precise role in neuronal remains largely unexplored.Using live imaging postnatal Rostral Migratory Stream (RMS)...
The fragile X syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is first monogenic cause autism spectrum disorder. FXS results from absence RNA-binding protein FMRP (fragile messenger ribonucleoprotein). Neuronal migration an essential step brain development allowing displacement neurons their germinal niches to final integration site. precise role in neuronal remains largely unexplored. Using live imaging postnatal rostral migratory stream (RMS) Fmr1...
ABSTRACT The Fragile X Syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is first monogenic cause Autism Spectrum Disorder. FXS results from absence RNA-binding protein FMRP (Fragile Messenger Ribonucleoprotein). Neuronal migration an essential step brain development allowing displacement neurons their germinal niches to final integration site. precise role in neuronal remains largely unexplored. Using live imaging postnatal Rostral Migratory Stream...